The object space task shows cumulative memory expression in both mice and rats

by Lisa Genzel, Evelien Schut, Tim Schr öder, Ronny Eichler, Mehdi Khamassi, Angela Gomez, Irene Navarro Lobato, Francesco Battaglia Declarative memory encompasses representations of specific events as well as knowledge extracted by accumulation over multiple episodes. To investigate how these different sorts of memories are created, we developed a new behavioral task in rodents. The task consists of 3 distinct conditions (stab le, overlapping, and random). Rodents are exposed to multiple sample trials, in which they explore objects in specific spatial arrangements, with object identity changing from trial to trial. In the stable condition, the locations are constant during all sample trials even though the objects themsel ves change; in the test trial, 1 object’s location is changed. In the random condition, object locations are presented in the sample phase without a specific spatial pattern. In the overlapping condition, 1 location is shared (overlapping) between all trials, while the other location changes durin g sample trials. We show that in the overlapping condition, instead of only remembering the last sample trial, rodents form a cumulative memory of the sample trials. Here, we could show that both mice and rats can accumulate information across multiple trials and express a long-term abstracted memor y.
Source: PLoS Biology: Archived Table of Contents - Category: Biology Authors: Source Type: research
More News: Biology