Dampening the fire to prevent surgery- and chemotherapy-induced metastasis
In this issue of the JCI, Panigrahy et al. demonstrate that preoperative administration of the antiinflammatory drug ketorolac or specialized proresolving mediators (SPM) called resolvins increases disease-free survival rates and prevents metastasis after surgery and chemotherapy in mouse models of cancer. The antitumor response was partially mediated by tumor-specific T cell immunity and immunological memory.
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Esra Güç, Jeffrey W. Pollard Source Type: research