Improved determination of femtogram-level organic explosives in multiple matrices using dual-sorbent solid phase extraction and liquid chromatography-high resolution accurate mass spectrometry.

Improved determination of femtogram-level organic explosives in multiple matrices using dual-sorbent solid phase extraction and liquid chromatography-high resolution accurate mass spectrometry. Talanta. 2019 Oct 01;203:65-76 Authors: Irlam RC, Parkin MC, Brabazon DP, Beardah MS, O'Donnell M, Barron LP Abstract Identification and trace quantification of multiple explosives residues, their precursors and transformation products in complex samples remains very challenging. For solid phase extraction (SPE) and liquid chromatography-high resolution accurate mass spectrometry-based methods (LC-HRMS), interferences from co-extracted matrix components can significantly affect recovery during extraction and/or detector signal. The aim of this work was to develop a new, improved and more generalisable extraction approach to trace explosives analysis in a range of matrices using dual-sorbent SPE with LC-HRMS. Recoveries of 44 organic explosives from model solutions were optimised and compared for seven different sorbents (Oasis HLB, HyperSep Retain PEP and Isolute ENV+, HyperSep SAX, HyperSep NH2, Strata Alumina-N and Bond Elut CN). On average, Oasis HLB and Isolute ENV+ yielded the best recoveries (>80%). For three sorbents, mean recoveries remained ≤1%, which made them potentially suitable for matrix removal when used in series with more analyte-selective sorbents. To evaluate matrix effects, a range of aqueous (river- and wastewater), ...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research