Activation of the Notch signaling pathway disturbs the CD4 + /CD8 + , Th17/Treg balance in rats with experimental autoimmune uveitis

ConclusionThe activation of the Notch signaling pathway can regulate Th17 and Treg cell differentiation, disrupt the CD4+/CD8+ and Th17/Treg balance, and aggravate the severity of EAU; inactivation of the Notch signaling pathway contributes to the CD4+/CD8+ and Th17/Treg balance in EAU rats. Our findings highlighted that the dynamic change in the CD4+/CD8+ and Th17/Treg ratio was consistent with the expression trend of Notch signaling in EAU rats, suggesting that Notch signaling may be a potentially important therapeutic target in clinical practice.

Source: Inflammation Research - June 16, 2019 Category: Research Source Type: research