RE: Straight-to-test faecal tagging CT colonography for exclusion of colon cancer in symptomatic patients under the English 2-week-wait cancer investigation pathway: a service review. A reply

Sir — We thank Laverty et al. for their correspondence and congratulations in response to our work.1 Please accept our apologies for the discrepancy in polyp categorisation. The revised polyp data in line with National Bowel Cancer Screening programme, the European Society of Gastrointestinal and Abd ominal Radiology (ESGAR) consensus guidelines2 and other published studies is as follows3,4: the total polyp detection rate was 13.5% (241 polyps) in 170 patients; 153 (63.5%) polyps were ≥10 mm in size compared to 88 (36.5%) measuring between 6–9 mm.
Source: Clinical Radiology - Category: Radiology Authors: Tags: Correspondence Source Type: research

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Abstract Objective: The main goal of our study was to assess the impact of vascular procedures on the activity of hemostatic and fibrinolytic pathways. Methods: We enrolled 38 patients with ≥ 45 years old undergoing surgery for abdominal aortic aneurysm or peripheral artery disease under general or regional anesthesia and who were hospitalized at least one night after the procedure. Patients undergoing carotid artery surgery and those who had acute bypass graft thrombosis, cancer, renal failure defined as estimated glomerular filtration rate
Source: Revista Brasileira de Cirurgia Cardiovascular - Category: Cardiovascular & Thoracic Surgery Source Type: research
Conclusions: the results showed an increased trend of elderly women dying of breast cancer in the region and with higher levels in the micro-regions with better indicators on living conditions.Resumo Objetivos: avaliar a rela ção entre as taxas corrigidas de mortalidade por câncer de mama e indicadores de condições de vida das idosas das microrregiões do Nordeste brasileiro. Métodos: adotou-se um estudo ecológico nos anos de 2010 e 2015 para as 188 microrregiões do Nordeste utilizando a modelagem de equações estruturais. Os dados de populaç&...
Source: Revista Brasileira de Saude Materno Infantil - Category: Midwifery Source Type: research
This study was carried out in accordance with approval of the Melbourne Health and Walter and Eliza Hall Institute of Medical Research's Human Research Ethics Committee (approval number: 2013.081). All subjects gave written informed consent for participation and publication. Results and Discussion TGF-β signaling in NK cells is associated with: phosphorylation in SMAD2 and 3, inhibition of IL-15-induced metabolism/proliferation, simultaneous downregulation of CD44, CD49e, and Eomes, and upregulation of CD16 and CD49a expression (7, 10). SMAD family member 4 (SMAD4) belongs to the SMAD family of transcription...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Endosc Int Open 2018; 06: E872-E877 DOI: 10.1055/a-0591-9308 Background and study aims UK Bowel Cancer Screening flexible sigmoidoscopy (BowelScope) currently offers patients aged 55 a one-off flexible sigmoidoscopy for adenoma clearance to decrease colorectal cancer incidence by interrupting the adenoma-carcinoma sequence. Recent evidence has shown maximum benefit in increasing adenoma detection rate (ADR) using the Endocuff Vision device in the left side of the colon and in screening patients. Currently, ADR is low and shows unacceptable variation in BowelScope. ADR is a quality indicator in screening sigmoidosco...
Source: Endoscopy International Open - Category: Gastroenterology Authors: Tags: Original article Source Type: research
Endoscopy DOI: 10.1055/s-0043-111718 Background and study aims Up to 25 % colorectal adenomas are missed during colonoscopy. The aim of this study was to investigate whether the endocuff could improve polyp detection in an organized bowel cancer screening program (BCSP). Patients and methods This parallel group, single-blinded, randomized controlled trial included patients with positive fecal occult blood test (FOBT) who were attending for BCSP colonoscopy. The primary outcome was the number of polyps per patient. Secondary outcomes included the number of adenomas per patient, adenoma and polyp detection ...
Source: Endoscopy - Category: Gastroenterology Authors: Tags: Original article Source Type: research
Conclusion Antibiotics, like all drugs, have side effects. We know that they affect the composition of bacteria that live in a healthy gut. This study suggests that might possibly be linked to future development of bowel cancer. However, there are some major limitations to keep in mind. Bowel polyps are very common, and they're not cancerous. Most people who have them won't know they're there, unless they have a colonoscopy. Some polyps do develop into bowel cancer, but we don't know if any of these women got bowel cancer, or how many of their polyps would have become cancerous if not treated. It's highly possible that wom...
Source: NHS News Feed - Category: Consumer Health News Tags: Cancer Medication Source Type: news
Extended use increases chance of polyps forming in the colon, adding weight to evidence gut bacteria plays a key role in cancer developmentThe overuse of antibiotics could increase a person ’s risk of developing bowel cancer, the findings of a US study suggest.Research published in medical journal Gut found extended use ofantibiotics significantly increased the chance of polyp formation in the colon, a precursor ofbowel cancer.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Bowel cancer Antibiotics Health Cancer research Medical research Science US news Australia news Source Type: news
(BMJ) Long-term antibiotic use in early to mid-life may be linked to a heightened risk of abnormal growths in the colon and rectum -- known as polyps or colorectal adenomas -- which precede the development of most cases of bowel cancer, reveals research published online in the journal Gut.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Endoscopic mucosal biopsy may misplace mucosal elements into the submucosa of colonic adenomas, mimicking invasive adenocarcinoma. Biopsy-related misplacement can be more challenging to recognize than typical misplaced epithelium (pseudoinvasion) in pedunculated polyps. We compared the features of 16 polyps with biopsy-related misplaced epithelium with those of 10 adenomas with pseudoinvasion and 10 adenomas with invasive adenocarcinoma and performed Ki67 and p53 immunostaining on all cases. Features of misplaced epithelium in polyps referred to the Bowel Cancer Screening Program Expert Board in the United Kingdom were als...
Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Original Articles Source Type: research
This study will take place across seven NHS Hospital Trusts: one in London and six within the Northern Region Endoscopy Group. A maximum of 10 colonoscopists per site will recruit a total of 1772 patients, with a maximum of four bowel screening colonoscopists permitted per site. Discussion: This is the first trial to evaluate the adenoma detection rate of Endocuff Vision™ in all screening, surveillance, and diagnostic patient groups. This timely study will guide clinicians as to the role of Endocuff Vision™ in routine colonoscopy.Study registration: ISRCTN11821044.[...]© Georg Thieme Verlag KG Stut...
Source: Endoscopy International Open - Category: Gastroenterology Authors: Tags: Original article Source Type: research
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