Oral vitamin a supplementation in very low birth weight neonates: a randomized controlled trial

Conclusions: Early postnatal oral VAS was associated with better composite outcome of all-cause mortality and oxygen requirement without any major adverse effects.Clinical Trial Registration: Clinical Trials Registry of India (CTRI/2017/03/008131).What is Known:•Postnatal intramuscular vitamin A supplementation improves the survival,respiratory outcome and other morbidities in very low birth weight neonates without major adverse effects.•Limited studies on oral vitamin A supplementation did not document substantial benefits.What is New:•Early postnatal alternate-day oral vitamin A supplementation at the dose of 10,000  IU/dose for 28 days improves the composite outcome of death and oxygen requirement in very low birth weight neonates with respiratory distress•No major adverse effects were documented
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research