Cortical Stimulation Accurately Guides Epilepsy Surgery Cortical Stimulation Accurately Guides Epilepsy Surgery

Inducing seizures with cortical stimulation accurately identifies the target area for resection and significantly reduces hospital stays, a new study shows.Medscape Medical News
Source: Medscape Pathology Headlines - Category: Pathology Tags: Neurology & Neurosurgery News Source Type: news

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ConclusionDespite the use of AEDs in the majority of patients, only one-third were seizure-free. Other challenges included polypharmacy, the use of valproate in women, and variable adherence. This points to a need for closer follow-up in patients with JME.Graphical abstract
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: Available online 19 July 2019Source: Redox BiologyAuthor(s): Tawfeeq Shekh-Ahmad, Andreas Lieb, Stjepana Kovac, Lukas Gola, Christian W. Wigley, Andrey Y. Abramov, Matthew C. WalkerAbstractMany epilepsies are acquired conditions following an insult to the brain such as a prolonged seizure, traumatic brain injury or stroke. The generation of reactive oxygen species (ROS) and induction of oxidative stress are common sequelae of such brain insults and have been shown to contribute to neuronal death and the development of epilepsy. Here, we show that combination therapy targeting the generation of ROS though ...
Source: Redox Biology - Category: Biology Source Type: research
Publication date: August 2019Source: Nutrition, Metabolism and Cardiovascular Diseases, Volume 29, Issue 8Author(s): Cinzia Ferraris, Valentina De Giorgis, Ilaria Brambilla, Monica Guglielmetti, Claudia Trentani, Lara Manea, Ottavia Ferraro, Simona Bertoli, Pierangelo Veggiotti, Anna Tagliabue
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
ConclusionsOur method is highly accurate, automated and non-parametric providing clinicians another tool that can be used to help identify the epileptogenic zone in patients undergoing the stereo electroencephalography procedure for epilepsy monitoring.
Source: Journal of Neuroscience Methods - Category: Neuroscience Source Type: research
Publication date: Available online 19 July 2019Source: Journal of Clinical NeuroscienceAuthor(s): Lu Yao, Wang Yue, Wu Xunyi, Wang Jianhong, Zhu Guoxing, Hong ZhenAbstractPurposeTo evaluate the clinical characteristics, treatment outcomes, prognosis and potential risk factors of patients in East China with seizure secondary to autoimmune encephalitis.MethodsFrom February 2014 to June 2016, 113 patients diagnosed with autoimmune encephalitis in Huashan Hospital, Fudan University, were enrolled in our study. After at least two years of follow-up, we retrospectively analyzed the patients’ clinical details, electroenceph...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
Introduction: The ketogenic diet (KD) is an effective therapeutic option for patients with drug-resistant epilepsy (EFR) and is the only therapy currently available for Glucose Transporter Type 1 Deficiency Syndrome (GLUT1-DS). Studies on long-term effects and, particularly, on growth are required.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - Category: Nutrition Authors: Source Type: research
The objective of this study was to develop and validate a highly sensitive HPLC-MS/MS assay capable of quantifying ondansetron in rat plasma and rat brain homogenate following a low subcutaneous administration of 1.0 µg/kg. Ondansetron was extracted by protein precipitation with methanol containing labeled ondansetron. The chromatography was performed on a Thermo Scientific Aquasil C18 analytical column (100 x 2.1 mm I.D., 5 μm) operating at 40 °C. The mobile phase consisted of acetonitrile and 10 mM ammonium formate pH 3 at a ratio of 30:70, respectively. The f...
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research
CONCLUSIONS: The overall use of AEDs in women of fertile age and pregnant women has increased in the past 16 years, especially due to an increased use of lamotrigine. However, valproate use in pregnant women and in younger women of fertile age has become less frequent. FUNDING: This study received funding from the Lundbeck Foundation, the Danish Epilepsy Association, the Central Denmark Region and the Novo Nordisk Foundation (NNF16OC0019126). TRIAL REGISTRATION: none. PMID: 31315793 [PubMed - in process]
Source: Danish Medical Journal - Category: General Medicine Tags: Dan Med J Source Type: research
AbstractPurpose of reviewChimeric antigen receptor T cell (CAR-T) adoptive cell therapy is an effective treatment for patients with refractory B cell malignancies. As its use has grown, there has been an increase in the incidence of a serious, potentially fatal neurotoxicity known as immune effector cell-associated neurotoxicity syndrome (ICANS). This review discusses the clinical manifestations of this neurotoxicity syndrome, current grading systems, management strategies, and proposed biologic mechanisms leading to neurotoxicity.Recent findingsCurrent research suggests that patients with a higher disease burden and highe...
Source: Current Treatment Options in Neurology - Category: Neurology Source Type: research
In this study, it was aimed to evaluate cognitive and behavioral changes after status epilepticus (SE) induced by pentylenetetrazole in immature rats via Morris water maze and open-field area tests and to assess alterations in expression of 84 key genes involved in synaptic plasticity after SE.MethodThe study was conducted on 30 immature rats (12-days old). The rats were assigned into groups as control and experiment (SE) groups. The SE was induced by pentylenetetrazole in 12-days old rats. In addition, experiment group was divided into two groups as mature (n = 8) and immature SE (n = 8) subgroups. Again, the cont...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
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