Comparison of BMD Changes and Bone Formation Marker Levels 3 Years After Bisphosphonate Discontinuation: FLEX and HORIZON ‐PFT Extension I Trials
We examined the proportion of participants with BMD loss or PINP gain ≥ least significant change (LSC) and those whose va lues exceeded a threshold (T‐score ≤–2.5 or PINP ≥36.0 ng/mL, a premenopausal median value). After 3 years of placebo, the FLEX group had greater mean total hip BMD decreases (–2.3% versus –1.2% in the HORIZON‐PFT E1 group,p
The intravenous therapies introduced for Acute Heart Failure (AHF) have remained almost unchanged in the last decades , although increasing short and long-term safety concerns have been reported regarding the use of inotropes/vasopressors  and use of Morphine [3,4].
Authors: Leggewie B, Zimmermann A, Strieth S, Gouveris H Abstract Sudden sensorineural hearing loss is not an emergency, but an urgency. Depending on severity, the disease may have a major impact on quality of life. Gold standard in Germany is a systemic, high-dosage glucocorticoid therapy. During oral or intravenous therapy with glucocorticoids, systemic side effects may occur. Especially in diabetics, this therapy may cause acute prominent disorders in glucose metabolism and therefore may be contraindicated. An alternative therapeutic option is intratympanic injection of steroids into the middle ear. He...
Conclusion: The peripherally inserted central catheter is a safe and reliable option for intravenous therapy in the pediatric oncology population. This study contributes to evidence the indication of its use for that population and appoints themes for future empirical studies.
Expert commentary is provided for a review of 39 RCTs (n=3,852) which found that death and cardiovascular death rates were not different for IV and oral iron. Questions remain about cost-effectiveness and tolerability of both oral and IV therapies.
This study demonstrates similar mortality among exposure groups in a large propensity matched cohort while highlighting the advantage of a decreased length of stay among patients on oral step-down therapy. The authors also evaluated mortality among those on oral-step down therapy with high vs low bioavailability, reflecting similar rates, but concluding their study was underpowered to evaluate this comparison. This point merits further discussion on the goal of power calculations, the article ’s power calculation, and the importance of accurate and transparent reporting of statistical analyses.
We present a case of a 49-year-old woman who acquired a highly multidrug-resistant Mycobacterium abscessus skin and soft-tissue infection after cosmetic abdominoplasty that required radical surgical debridement and 6 months of intravenous therapy to eradicate. This case highlights the challenges in the management of M. abscessus infections including delay to diagnosis and resistance patterns that are likely to become more common despite antibiotic stewardship efforts.
PMID: 31108520 [PubMed - in process]
Across Canada, private clinics charge thousands of dollars for injections and IV therapies using what they claim are stem cells. This week, Health Canada ruled that those cell therapies are drugs that must be approved. But so far, the agency has not ordered clinics to stop doing the procedures.