Is sleep the secret to early Alzheimer's diagnosis?

Changes to two kinds of sleep brain waves that tend to occur with age predict the build up of tau tangles and beta-amyloid plaques -harbingers of Alzheimer's - a new UC Berkeley study suggests.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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PET images have uncovered consistently greater accumulation of tau protein...Read more on AuntMinnie.comRelated Reading: PET, MRI show physical activity aids brain health PET links sleep and beta-amyloid accumulation How do seniors react to amyloid-PET results? PET study links menopausal status to Alzheimer's FDG-PET links physical activity to healthy brains
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
This popular science article from the AARP is representative of the sort of outsider's view of the longevity industry that is presently dominant. On the one hand, it is good that the media and advocacy organizations such as AARP are finally talking seriously about treating aging as a medical condition. On the other hand, the author looks at two of the most popular areas of development, mTOR inhibitors and senolytics, in a way that makes them seem more or less equivalent, and then further adds diet and exercise as another equivalent strategy. This will be continuing issue, I fear. People, as a rule, don't think about size o...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Frequent use of sleep medications appears to be associated with increased long-term risk of dementia, particularly among older white adults, according to research presented at the Alzheimer's Association International Conference in Los Angeles this week.“Based on our findings, we recommend that clinicians make more effort to be aware of their patients’ sleep problems including use of sleep aids,” said lead study author Yue Leng, Ph.D., of the University of California, San Francisco, in apress release.Leng and colleagues studied 3,068 black and white community-dwelling older adults aged 70 to 79 years who ...
Source: Psychiatr News - Category: Psychiatry Tags: Association International Conference dementia Los Angeles older white adults sleep medications Source Type: research
Neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD) are important health problems and there is a growing recognition that both governmental and non-governmental organizations must make efforts to prevent, in addition to treat, them. In this context, the pineal product melatonin has a promising significance. Melatonin, an unusual phylogenetically conserved molecule present in all known aerobic organisms, is effective both as a chronobiotic and as a cytoprotective. As a chronobiotic, the afternoon increase in melatonin "opens the doors of sleep" every night and the therapeutic u...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
There hasn’t been much good news about Alzheimer’s lately, between the March announcement by Biogen and Esai that a promising trial of a potential drug treatment failed, and the July decision by Novartis and Amgen to stop their study of another class of therapies for the neurodegenerative disease. But in a pair of studies presented at the annual Alzheimer’s Association International Conference on July 14, researchers reported encouraging results from studies of non-drug approaches. In one, scientists led by Dr. Klodian Dhana at Rush University Medical Center in Chicago followed nearly 2,500 people for alm...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Alzheimer's Brain embargoed study Source Type: news
Alzheimer ’s disease (AD) is a globally common neurodegenerative disease, which is accompanied by alterations to various lifestyle patterns, such as sleep disturbance. The pineal gland is the primary endocrine ...
Source: Molecular Neurodegeneration - Category: Neurology Authors: Tags: Review Source Type: research
AbstractConcurrent mild traumatic brain injury (mTBI) and posttraumatic stress disorder (PTSD) are common in U.S. military service members and veterans. Tau and amyloid ‐beta‐42 (Aβ42) are proteins that have been linked to cognitive impairment, neurological hallmarks of Alzheimer's disease, and may also relate to recovery from mTBI. However, the role of these proteins in the maintenance or resolution of chronic symptoms has not yet been determined. Participant s in the current study were 102 service members and veterans who had sustained an mTBI (n = 84) or injured controls (IC) without TBI (n = 18). They were cat...
Source: Journal of Traumatic Stress - Category: Psychiatry & Psychology Authors: Tags: RESEARCH ARTICLE Source Type: research
AbstractPurpose of ReviewDeveloping pharmacological treatments to manage neuropsychiatric symptoms of Alzheimer ’s disease is of high importance due to its significant association with poorer outcomes, caregiver burden, and severity of disease. Due to limited effective and safe treatment options, we reviewed emerging research in novel pharmacological agents for the management of neuropsychiatric symptoms in Alzheimer’s disease.Recent FindingsWithin the past 5  years, 29 novel pharmacological agents to treat the neuropsychiatric symptoms of Alzheimer’s disease have been investigated or are currently i...
Source: Current Behavioral Neuroscience Reports - Category: Neuroscience Source Type: research
In this study, animals had free individual access to wheels to practice voluntary exercise. The Barnes Maze (BM) task was conducted with young and aged O. degus animals after combining voluntary exercise and either normal sleep or SD. Plasma cortisol levels were measured after each condition. SD impaired hippocampus-dependent memory in both young and old animals, while cortisol levels did not significantly differ between non-SD and SD animals. However, voluntary exercise for 45 days improved the cognitive impairment caused by SD compared with the control condition. Moreover, voluntary exercise decreased plasma cortisol lev...
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research
(Northwestern University) Gentle sound stimulation played during deep sleep enhanced deep sleep for people with mild cognitive impairment, who are at risk for Alzheimer's disease, a new study found. Those whose brains responded the most robustly to the sound stimulation showed an improved memory response the following day. These results suggest improving sleep is a promising novel approach to stave off dementia. The technology can be adapted for home use.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
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