Invitae Takes a Deeper Dive into NIPS with New M & amp;A Target

Invitae’s latest acquisition is set to firmly entrench the genetics company in the non-invasive prenatal screening (NIPS). The San Francisco-based company said it signed a definitive agreement to acquire Singular Bio for $55 million. Singular Bio specializes in developing single molecule detection technology that enables lower costs and expanded use of high-quality, cell-free, nucleic acid analysis, initially for application in NIPS. The acquisition is expected to close in the coming weeks, subject to customary closing conditions. Invitae noted the transaction will be cash neutral at close and has already factored in the additional operating expense of this acquisition in prior statements about expected 2019 cash burn. "Since we began, Invitae has invested deeply to harness the power of the most advanced genetic testing technologies in order to deliver expert-level genetic information at scale and bringing this company into Invitae is the next step in that process," Sean George, PhD, co-founder and CEO of Invitae, said in a release. "Singular Bio is building an approach to non-invasive prenatal screening with the potential to achieve the cost savings necessary to provide more women with genetic information to support a healthy pregnancy. We believe this approach could eventually be applied to other areas of genetic testing. The addition of Singular Bio's technology will further strengthen our ability to bring genetic information into mainstrea...
Source: MDDI - Category: Medical Devices Authors: Tags: IVD Source Type: news

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Authors: Burns EA, Ahmed A, Sunkara A, Khan U, Sharif R, Abdelrahim M, Reardon M, Trachtenberg B Abstract Primary cardiac angiosarcoma (PCAS) is a malignancy seldom seen in pregnancy. A 23-year-old G1P0 Chinese female was found to have PCAS during her first trimester when she presented with tamponade physiology. The transthoracic echocardiography (TTE) results did not indicate the presence of an intracardiac lesion, and pericardial fluid cytology analysis showed no evidence of malignancy. Cardiac magnetic resonance imaging (CMRI) exhibited a right atrial mass, and tissue biopsy indicated a high-grade angiosarcoma. ...
Source: Ecancermedicalscience - Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research
CONCLUSIONS: Outcome-specific criteria are an important part of a systematic review and will facilitate study evaluations by epidemiologists with experience in evaluating studies using systematic review methods who may not have extensive discipline-specific experience in the outcomes being reviewed. PMID: 31299560 [PubMed - as supplied by publisher]
Source: Environment International - Category: Environmental Health Authors: Tags: Environ Int Source Type: research
The human fetus is a long way from having a heartbeat just six weeks into pregnancy, but experts say the abortion-tied term can be harmful right away.
Source: Healthcare News - Category: Pharmaceuticals Authors: Source Type: news
The human fetus is a long way from having a heartbeat just six weeks into pregnancy, but experts say this language can be harmful right away.
Source: Healthcare News - Category: Pharmaceuticals Authors: Source Type: news
ConclusionsThere are multiple factors associated with the increased LOS seen in patients with thermal and inhalation injury. This study confirmed and identified novel factors not previously discussed in the literature that were significantly associated with LOS. Expansion of the data submitted to the National Burn Repository and the Burn Quality Improvement Program may be warranted. This study confirms claims from previous studies on inadequacy of current data submitted for benchmarking and under-reimbursement for the care of such a complex population.
Source: Burns - Category: Dermatology Source Type: research
This study e...
Source: BMC Pediatrics - Category: Pediatrics Authors: Tags: Research article Source Type: research
This study aimed to evaluate adherence to antihypertensive treatment amongst pregnant women with chronic hypertension using high-performance liquid chromatography-tandem mass spectrometry instrumentation. Spot urine samples collected from women who were randomised to labetalol or nifedipine were assessed. Samples from 74 women were included; documented prescribing and urine metabolite detection were concordant in 88% (n=65). Evidence of self-administration of alternative treatment was observed in 8% (n=6). Measurement of urinary antihypertensive metabolites in pregnancy provides insight into treatment adherence.
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
In this study, we reviewed major human studies on the health risks of radiation exposure and showed that sex-related factors may potentially influence the long-term response to radiation exposure. Available data suggest that long-term radiosensitivity in women is higher than that in men who receive a comparable dose of radiation. The report on the biological effects of ionizing radiation (BEIR VII) published in 2006 by the National Academy of Sciences, United States emphasized that women may be at significantly greater risk of suffering and dying from radiation-induced cancer than men exposed to the same dose of radiation....
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Most women who have a caesarean can safely have a vaginal birth after caesarean (VBAC) for their next birth, but more women have an elective repeat caesarean than a VBAC.
Source: BMC Pregnancy and Childbirth - Category: OBGYN Authors: Tags: Research article Source Type: research
By Margarite Nathe, Principal Editor/Writer, IntraHealth InternationalApril 26, 2019There ’s no stopping the changes coming to the development sector. But let’s be smart about them.Sometimes,Dai Hozumi says, innovation sucks.“We’re in sort of an innovation fever these days,” IntraHealth International’s chief technical officer said to the crowd today in Saxapahaw, North Carolina. “It’s one of the most common words I’ve heard here at SwitchPoint. As an MD, I have the right to diagnose your symptoms and I’m telling you, you have innovation fever.”It ’s ...
Source: IntraHealth International - Category: International Medicine & Public Health Authors: Tags: SwitchPoint Source Type: news
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