Pride in the Diversity of NIH

During this first awards program the Office of Equity, Diversity and Inclusion (EDI) will honor these NIH employees and fellows who are community members and allies nominated for their exemplary work helping to create safer spaces for SGM at the NIH. These awardees lead by example and encourage others to demonstrate unconditional compassion, leadership, and understanding towards members of the SGM community: Dr. Vivian Ota Wang, National Cancer Institute; Dr. Christopher Wheldon, National Cancer Institute; Adam Cornish, National Institute on Aging; Dr. Karen Parker, Sexual&Gender Minority Research Office, Tricia Coffey, Clinical Center; Dr. Victoria Cargill, Office of Research on Women's Health; and Gabriela Zabala-Aleman, Office of Intramural Training and Education.For more information go tohttps://www.edi.nih.gov/people/sep/lgbti/pride-2019Air date: 6/20/2019 2:00:00 PM
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video

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ABSTRACT Objective Review the diet and nutritional status of women surviving breast cancer following the Dietary Guidelines for the Brazilian Population. Methods A cross-sectional study was conducted with 201 women, who underwent anthropometric measurements to determine body mass index, waist circumference and waist/hip ratio. Dietary assessment was performed usinga food frequency questionnaire. Consumption was stratifi ed into four groups: fresh/minimally processed food (Group 1), processed food ingredients (Group 2), processed food (Group 3) and ultra-processed food (Group 4).The ratio of daily contribution of each food ...
Source: Revista de Nutricao - Category: Nutrition Source Type: research
Publication date: Available online 16 October 2019Source: Pharmacology &TherapeuticsAuthor(s): Stephen J. Bagley, Donald M. O’RourkeAbstractChimeric antigen receptor (CAR) T cells are a form of autologous immunotherapy that has changed the therapeutic landscape of hematologic malignancies. CAR T cell therapy involves collection of a patient’s T cells by apheresis, ex vivo genetic modification of the T cells to encode a synthetic receptor that binds a specific tumor antigen, and infusion of the T cells back into the patient. With the unprecedented success of CAR T cells in leukemia and lymphoma, a growing nu...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 16 October 2019Source: Pharmacology &TherapeuticsAuthor(s): Suya Wang, Jianshi Yu, Maureen A. Kane, Alexander R. MoiseAbstractThe vitamin A metabolite, retinoic acid, is an important signaling molecule during embryonic development serving critical roles in morphogenesis, organ patterning and skeletal and neural development. Retinoic acid is also important in postnatal life in the maintenance of tissue homeostasis, while retinoid-based therapies have long been used in the treatment of a variety of cancers and skin disorders. As the number of people living with chronic disorders continu...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 16 October 2019Source: Pharmacological ResearchAuthor(s): Siqi Feng, Huan Wang, Jiali Liu, Jiye AA, Fang Zhou, Guangji WangAbstractKetone bodies are traditionally viewed as metabolic substrates in carbohydrate restriction and are applied in the treatment of epilepsy and other neurodegenerative diseases. Recently, people have paid more attention to its application in the treatment for cancers. Compared to normal cells, cancer cells maintain a higher level of reactive oxygen species (ROS) due to the dysfunctional oxidative phosphorylation and they highly rely on glucose for glycolysis and p...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Conclusions: Our findings suggested that Dulcitol acted as a SIRT1 inhibitor, inducing apoptosis and inhibiting proliferation, migration and invasion of HepG2 cells and its modulatory mechanism seemed to be associated with regulation of MMPs, SIRT1/p53 pathways.Graphical abstractSchematic diagram of the proposed mechanisms of Dulcitol-induced apoptosis and anti-metastasis in hepatocellular carcinoma in vivo and in vitro.
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
Abstract The species Kalanchoe laciniata (L.) DC. and Bryophyllum pinnatum (Lam) Pers. are native from Brazil and Madagascar, respectively. Both belonging to the Crassulaceae family and being widely used by population as a natural anti-inflammatory agent. These species have similar leaf morphology and for this reason, they are known by the same popular name as “ sai ão ” or “ coirama ” . Several studies have been published involving different parts and preparations of these species. Therefore, this review aims to provide an update overview about the traditional uses, chemical constitution, ph...
Source: Revista Brasileira de Farmacognosia - Category: Drugs & Pharmacology Source Type: research
Garner posted a video on Instagram, and it ’s already “Garnered” over 1.7 million views and over 300,000 likes.
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Source Type: news
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
Publication date: January 2020Source: Materials Science and Engineering: C, Volume 106Author(s): O. Mitxelena-Iribarren, J. Campisi, I. Martínez de Apellániz, S. Lizarbe-Sancha, S. Arana, V. Zhukova, M. Mujika, A. ZhukovAbstractLimitations in effectiveness and the invasive nature of current cancer treatment options emphasize the need for further clinical advancements. Among other approaches, targeted hyperthermia is as a new strategy aimed at targeting cancerous cells to improve the efficacy of radiotherapy or cytotoxic drugs. However, the testing of magnetic vehicles has mainly focused on the use of nanopart...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: January 2020Source: Materials Science and Engineering: C, Volume 106Author(s): Ghizlane Choukrani, Bikendra Maharjan, Chan Hee Park, Cheol Sang Kim, Arathyram Ramachandra Kurup SasikalaAbstractA promising candidate for the development of controlled and targeted nanoscale drug delivery system but less studied so far is calcium carbonate (CaCO3) in the form of porous polycrystalline vaterite spheres. Vaterite has been shown to exhibit various beneficial properties such as excellent biocompatibility, high drug loading capacity, and pH-sensitive decomposition under mild conditions. However, fabricating vateri...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
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