Pyrrole 2-carbaldehyde derived alkaloids from the roots of Angelica dahurica

AbstractSix new pyrrole 2-carbaldehyde derived alkaloids, dahurines A–F (1–6), along with five known ones (7 –11) and butyl 2-pyrrolidone-5-carboxylate (12) were isolated from the roots ofAngelica dahurica. Their structures were determined by extensive spectroscopic and spectrometric data (1D and 2D NMR, IR, and HRESIMS) and calculated electronic circular dichroism (ECD) methods. Although compounds7 and8 have been chemically synthesized, they were obtained from natural materials for the first time. Compounds2,3,4,10, and11 exhibited acetylcholinesterase inhibitory activity with IC50 values in the range of 47.5 –52.5 μM.Graphic abstractPyrrole 2-carbaldehyde derived alkaloids from the roots ofAngelica dahurica
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research