Ability of known susceptibility SNPs to predict colorectal cancer risk for persons with and without a family history

AbstractBefore SNP-based risk can be incorporated in colorectal cancer (CRC) screening, the ability of these SNPs to estimate CRC risk for persons with and without a family history of CRC, and the screening implications need to be determined. We estimated the association with CRC of a 45 SNP-based risk using 1181 cases and 999 controls, and its correlation with CRC risk predicted from detailed family history. We estimated the predicted change in the distribution across predefined risk categories, and implications for recommended screening commencement age, from adding SNP-based risk to family history. The inter-quintile risk ratio for colorectal cancer risk of the SNP-based risk was 3.28 (95% CI 2.54 –4.22). SNP-based and family history-based risks were not correlated (r  =  0.02). For persons with no first-degree relatives with CRC, screening could commence 4 years earlier for women (5 years for men) in the highest quintile of SNP-based risk. For persons with two first-degree relatives with CRC, screening could commence 16 years earlier for men and women in the h ighest quintile, and 7 years earlier for the lowest quintile. This 45 SNP panel in conjunction with family history, can identify people who could benefit from earlier screening. Risk reclassification by 45 SNPs could inform targeted screening for CRC prevention, particularly in clinical genetics se ttings when mutations in high-risk genes cannot be identified. Yet to be determ...
Source: Familial Cancer - Category: Cancer & Oncology Source Type: research

Related Links:

AbstractDiffusing alpha-emitters radiation therapy (DaRT) is the only known method for treating solid tumors with highly destructive alpha radiation. More importantly, as a monotherapy, DaRT has been shown to induce a systemic antitumor immune response following tumor ablation. Here, immunomodulatory strategies to boost the antitumor immune response induced by DaRT, and the response specificity, were investigated in the colon cancer CT26 mouse model. Local treatment prior to DaRT,  with the TLR3 agonist poly I:C, was sufficient to inhibit tumor growth relative to poly I:C or DaRT alone. DaRT used in combination with t...
Source: Cancer Immunology, Immunotherapy - Category: Cancer & Oncology Source Type: research
ConclusionsTreatment of anal cancer results in low rates of salvage surgery and permanent ostomies, when therapy was determined by a multidisciplinary team following national and international guidelines.
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
Eupafolin is the main bioactive component extracted from the traditional Chinese medicine Ay Tsao (Artemisia vulgaris L.), and its anti-tumor activity has had been studied in previous researches. T-LAK cell-originated protein kinase (TOPK) belongs to serine/threonine protein kinase and is highly expressed in several cancer cells and tissues, such as colon cancer, lung cancer, esophagus cancer, and so on. Therefore, it was recognized as an important target for treating tumors. Nowadays, we found that eupafolin suppressed TOPK activities at the first time in vitro and in vivo. The cells study indicated that eupafolin suppres...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Background and Objective: Hepatocyte nuclear factor 3β (HNF3β) is a key transcription factor in the development of the gastrointestinal tract. However, only few studies have examined its' expression, function and potential clinical significance in colorectal cancer tumorigenesis and progression.Methods: HNF3β expression in colorectal cancer tissue samples of 174 patients was assessed by immunohistochemistry. The results were analyzed with respect to patients' clinicopathological characteristics and survival. Following the in vitro cell transfection, MTT, wound healing, and Transwell assays were used to test ...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
A new clinical practice guideline challenges the validity of routine colorectal cancer screening beneath a certain risk threshold. Dr David Johnson advises caution about adopting its recommendations.Medscape Gastroenterology
Source: Medscape Gastroenterology Headlines - Category: Gastroenterology Tags: Gastroenterology Commentary Source Type: news
ConclusionsPatients undergoing resection of colorectal cancer cluster into different groups based on LOS of the index admission. Those with prolonged LOS were more likely to develop adverse outcomes within 30  days after discharge. Some of the strongest independent predictors of prolonged LOS, such as surgical infections or open surgery, could be modified to reduce LOS and, in turn, other adverse outcomes.Trial registrationNCT02488161
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
ConclusionsPhysical and psychological functioning, pain, fatigue and appetite loss had prognostic significance above and beyond clinical predictors in CRC. Routine monitoring of these PROs may allow earlier detection and amelioration of problems, which may improve quality of life and perhaps extend survival. More research is needed to determine prognostic value of PROs in early-stage CRC, and prognostic significance of changes in PRO scores.
Source: Quality of Life Research - Category: Health Management Source Type: research
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.9b00867
Source: Molecular Pharmaceutics - Category: Drugs & Pharmacology Authors: Source Type: research
Publication date: Available online 19 October 2019Source: Food ChemistryAuthor(s): Carina Alexandra Rodrigues, Antonio Eduardo Nicácio, Joana Schuelter Boeing, Franciele Pelegrin Garcia, Celso Vataru Nakamura, Jesuí Vergílio Visentainer, Liane MaldanerAbstractDespite the numerous studies that have shown a wide range of biological activities to berry fruits, scientific data focusing on modern, rapid and simple extraction methods followed by a clean-up step is still lacking. Therefore, the present work was aimed at investigating the use of a fast one-step liquid–solid extraction procedure followed ...
Source: Food Chemistry - Category: Food Science Source Type: research
More News: Cancer | Cancer & Oncology | Colorectal Cancer | Genetics | Insurance | Legislation | Medical Ethics | Women