Early-Life Biomarkers for Psychosis Risk in Young People: Another Nail in the Coffin for Cartesian Dualism

Disorders of the brain are not confined to this precious lump of fat that is typically thought to be shielded from rest of the body by the blood-brain barrier. Accumulating evidence now challenges Cartesian dualism by demonstrating that many brain disorders, including schizophrenia and depression, involve multiple systems (1). In this issue of Biological Psychiatry, Madrid-Gambin et  al. (2) report a case-control study nested in the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort on the association of psychotic experiences (PEs) in young adults assessed around 18 years of age with blood lipidomics, proteomics, and complement/coagulation protein biomarkers in childhood at 12 years of age.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Commentary Source Type: research

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Suicide is an important public health problem. The most frequent psychiatric illnesses associated with suicide or severe suicide attempt are mood and psychotic disorders. The purpose of this paper is to provide an educational overview of suicidal behavior ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Research Methods, Surveillance and Codes, Models Source Type: news
BACKGROUND: It is still unknown whether many well-identified risk factors of suicide could be applied to the elderly Chinese patients with schizophrenia. METHODS: 1-month suicidal ideation and lifetime suicide attempts together with their sociodemo...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Publication date: Available online 13 July 2019Source: Brain, Behavior, and ImmunityAuthor(s): Seyma Katrinli, Adriana Lori, Varun Kilaru, Sierra Carter, Abigail Powers, Charles F. Gillespie, Aliza P. Wingo, Vasiliki Michopoulos, Tanja Jovanovic, Kerry J. Ressler, Alicia K. SmithAbstractBackgroundImmune dysregulation has been widely observed in those with posttraumatic stress disorder (PTSD). An individual’s immune response is shaped, in part, by the highly polymorphic Human Leukocyte Antigen (HLA) locus that is associated with major psychiatric disorders such as schizophrenia, major depression and bipolar disorder. ...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
Conclusions for the primary outcome did not substantially change after adjusting for possible effect moderators or in sensitivity analyses (eg, when excluding placebo-controlled studies). The confidence in evidence was often low or very low.InterpretationThere are some efficacy differences between antipsychotics, but most of them are gradual rather than discrete. Differences in side-effects are more marked. These findings will aid clinicians in balancing risks versus benefits of those drugs available in their countries. They should consider the importance of each outcome, the patients' medical problems, and preferences.Fun...
Source: The Lancet - Category: General Medicine Source Type: research
CONCLUSION: In our knowledge, there is not any previous systematic review defining the neuropsychological profile of GAD. Due to the clinical and functional consequences of cognitive symptoms in these patients, future studies that allow a better knowledge on this field are needed: including larger samples of patients; controlling variables that could eventually modify the association between cognitive symptoms and GAD, such as pharmacological treatment and comorbid depression; focusing on specific neuropsychological test for GAD; and evaluating the effect of pharmacological and psychological treatment on cognitive symptoms...
Source: Revista de Neurologia - Category: Neurology Authors: Tags: Rev Neurol Source Type: research
   One of the most dangerous misconceptions about suicide is that asking a loved one if they are suicidal will increase the odds that they will attempt suicide.  Today Dr. Nate Ivers of Wake Forest University discusses the importance of making “the covert overt” by asking blunt, straightforward questions of those you suspect may be thinking about suicide.  What words should you use, and if the answer is yes, what should you do next?  And why are we so uncomfortable about asking these potentially lifesaving questions? Find out on this episode. SUBSCRIBE &REVIEW   Guest inform...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Depression Grief and Loss Suicide The Psych Central Show Source Type: blogs
Abstract Suicide is an important public health problem. The most frequent psychiatric illnesses associated with suicide or severe suicide attempt are mood and psychotic disorders. The purpose of this paper is to provide an educational overview of suicidal behavior in individuals with schizophrenia. A lifetime suicide rate in individuals with schizophrenia is approximately 10%. Suicide is the largest contributor to the decreased life expectancy in individuals with schizophrenia. Demographic and psychosocial factors that increase a risk of suicide in individuals with schizophrenia include younger age, being male, be...
Source: Medicina (Kaunas) - Category: Universities & Medical Training Authors: Tags: Medicina (Kaunas) Source Type: research
We report here the first study to systematically seek and collate service user perspectives on a major classification and diagnostic guideline. Focus groups were used to collect feedback on five diagnoses: depressive episode, generalised anxiety disorder, schizophrenia, bipolar type 1 disorder, and personality disorder. Participants were given the official draft diagnostic guidelines and a parallel lay translation. Data were then thematically analysed, forming the basis of co-produced recommendations for WHO, which included features that could be added or revised to better reflect lived experience and changes to language t...
Source: The Lancet Psychiatry - Category: Psychiatry Source Type: research
Abstract Chronic social stress and/or pharmacological treatments differentially modulate the expression of c-Fos, a marker of neuronal activity, in subregions of the rat brain. Here, we examined the effect of the atypical antipsychotic Clozapine (Clz) (20 mg/kg/day for 3 weeks) on the neuronal activation pattern of c-Fos protein expression in stress-relevant brain subregions of adult male Wistar rats exposed to chronic social isolation (CSIS: 3 weeks), an animal model of depression and schizophrenia, and controls. The protein expression of c-Fos was also used to map neuronal populations in brain subregions ...
Source: Brain Research Bulletin - Category: Neurology Authors: Tags: Brain Res Bull Source Type: research
Patients with schizophrenia and related psychotic disorders continue to experience cognitive decline for years after illness onset, according to astudy inAJP in Advance.“While large deficits in processing speed are already apparent at the first episode [of psychosis], deficits in verbal knowledge and memory continue to increase,” wrote Jolanta Zanelli, Ph.D., of King’s College London and colleagues. Understanding these differences can help guide cognitive rem ediation therapy in patients, the authors noted.These findings were based on data collected as part of the Aetiology and Ethnicity in Schizophrenia ...
Source: Psychiatr News - Category: Psychiatry Tags: AESOP Aetiology and Ethnicity in Schizophrenia and Other Psychoses ajp in advance cognitive decline first-episode psychosis IQ Jolanta Zanelli memory verbal skills Source Type: research
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