Role of carotid ultrasound in addition to SCORE for the cardiovascular risk stratification of patients with psoriatic arthritis.
CONCLUSION: A considerable number of PsA patients have clinical estimated intermediate or high risk of a fatal CV event. Carotid US study detects subclinical vascular disease and may be useful to depict the real risk. The presence of atheroma is only partially explained by the classical CV risk factors. PMID: 31203214 [PubMed - as supplied by publisher]
AbstractIntroduction/objectiveApremilast, PDE4 competitive inhibitor, has been recently introduced in the treatment of adult psoriatic arthritis (PsA) patients, but only preliminary data are available on imaging evaluation. Thus, we evaluated the response to apremilast in PsA patients by ultrasonographic (US) assessment.MethodsThirty-four patients (M/F 7/27; median age 61 years, IQR 15; median disease duration 10 years, IQR 13) treated for polyarticular involvement were longitudinally evaluated. All the patients were assessed at baseline (T0), and after 6 (T1), 12 (T2), and 24 weeks (T3) by DAS28, CDAI, SDA...
The objective of this study was to compare the clinical and ultrasonographic features of symptomatic with asymptomatic psoriatic arthritis (PsA) dactylitis.MethodsOne hundred and twenty-five hand dactylitis were evaluated in a multicenter cross-sectional study for the presence of pain, subjective functional limitation, and tenderness (4-points scale) with the calculation of a Leeds Dactylitis Index (LDI) score. Fingers were subsequently investigated using high-frequency ultrasound (US) both in gray-scale (GS) and power Doppler (PD), for the presence and grading of flexor tenosynovitis, soft tissue edema, subcutaneous PD si...
Conclusion: MASEI demonstrates to be a reliable tool in PsA. All enthesis US Doppler definitions demonstrate to be reliable for its use in PsA with minimal differences, being PD MASEI the most sensitive in active patients. PMID: 31210075 [PubMed - as supplied by publisher]
In patients with PsA involving the hands, structural alterations of the dominant hand assessed by conventional x-ray and ultrasound are associated with loss of strength measured objectively with dynamometry and greater disability also studied subjectively using the HAQ.
(Wiley) Patients with psoriasis and psoriatic arthritis -- collectively termed psoriatic disease -- face increased heart risks. A new study published in Arthritis&Rheumatology indicates that ultrasound imaging of the carotid arteries can reveal the extent to which patients' arteries are clogged and also indicate their risk of experiencing future cardiovascular events.
Authors: PMID: 31154450 [PubMed - in process]
Conditions: Psoriatic Arthritis; Psoriasis; Enthesitis Interventions: Biological: adalimumab; Biological: Certolizumab; Biological: Etanercept; Biological: Golimumab; Biological: Secukinumab Sponsors: Belfast Health and Social Care Trust; British Medical Association; Psoriasis and Psoriatic Arthritis Alliance; Queen's University, Belfast Recruiting
Authors: Girolimetto N, Macchioni P, Tinazzi I, Costa L, McGonagle D, Peluso R, Del Puente A, Addimanda O, Marchetta A, Possemato N, Tasso M, Salvarani C, Scarpa R, Caso F Abstract OBJECTIVE: To use ultrasonography to explore whether the duration of psoriatic dactylitis was associated with different patterns of extracapsular and synovial based involvement. METHODS: One hundred cases of hand dactylitis from 85 psoriatic arthritis (PsA) patients were consecutively enrolled in a multicentre cross-sectional study and divided into two groups according to dactylitis duration (shorter or longer than the median: 20 wee...
ConclusionUltrasonography is superior to clinical examination in detection of enthesitis in SpA patients with good sensitivity and specificity. Enthesitis is common in upper limbs as it is in lower limbs; pathological findings and predictive values of calcifications and erosions were high at entheses of upper limbs especially supraspinatus.