The intermittent administration of ethanol during the juvenile period produces changes in the expression of hippocampal genes and proteins and deterioration of spatial memory.
CONCLUSIONS: Excessive and intermittent ethanol exposure during adolescence impaired the spatial memory processes during adulthood regardless of the amount of alcohol administered. Moreover, chronic-moderate and intermittent pattern induced changes in the expression of glutamatergic receptors. In addition, high-intermittent ethanol exposure during adolescence inactivated GSK3β by increasing its phosphorylation in Ser9. PMID: 31201872 [PubMed - as supplied by publisher]
Publication date: Available online 18 October 2019Source: International Journal of PsychophysiologyAuthor(s): Julia B. McDonald, Melanie L. Bozzay, Konrad Bresin, Edelyn VeronaAbstractA prominent characteristic of externalizing psychopathology is the inability to suppress or modulate behavioral responses and impulses. These tendencies have been associated with cognitive indicators of inhibitory control (P3) and error processing (error-related negativity [ERN] and positivity [Pe]). However, the extent to which these trait-like components are characteristic of specific manifestations, or externalizing proneness more generall...
Publication date: 19–25 October 2019Source: The Lancet, Volume 394, Issue 10207Author(s): Sally Casswell
Publication date: Available online 17 October 2019Source: Trends in Endocrinology &MetabolismAuthor(s): Daniela Stols-Gonçalves, G. Kees Hovingh, Max Nieuwdorp, Adriaan G. HolleboomThe prevalence of non-alcoholic fatty liver disease (NAFLD) is strongly increasing and may put patients at increased risk for atherosclerotic cardiovascular disease (asCVD). Both disease phenotypes often co-occur, in the case of obesity, insulin resistance, diabetes mellitus type 2, and the metabolic syndrome. We explore the pathogenesis of NAFLD, the epidemiology of asCVD in NAFLD patients, shared drivers of both phenotypes, and fact...
CONCLUSION: Based on these findings, flavonoids present in hydroalcoholic extract may be developed into drug for clinical application for the treatment of thrombosis in patients. PMID: 31622211 [PubMed - as supplied by publisher]
Conclusion: In conclusion, cannabis, alcohol and cigarette use were prevalent in the acute period post-concussion; however, were not observed to impact recovery within the first 4 weeks post-injury. Amongst unrecovered individuals, acute cannabis use was associated with lower symptom burden, while cigarette use was associated with greater initial symptom burden. PMID: 31621424 [PubMed - as supplied by publisher]
We present a very unusual initial presentation of occult HCC with peritoneal carcinomatosis secondary to liver rupture in a 70-year-old man with known nonalcoholic steatohepatitis–cirrhosis, best appreciated on FDG PET/CT. Our patient died a few days later. Tumor rupture is a rare but usually rapidly lethal complication of HCC.
Conditions: Nonalcoholic Fatty Liver Disease; Physician Interventions: Other: Interview; Other: Questionnaire Administration Sponsors: M.D. Anderson Cancer Center; National Cancer Institute (NCI) Recruiting
New research finds that frequent low alcohol consumption, such as one daily drink, has a higher risk of atrial fibrillation than infrequent binge drinking.
Publication date: Available online 17 October 2019Source: The Lancet PsychiatryAuthor(s): Justin Knox, Deborah S Hasin, Farren R R Larson, Henry R KranzlerSummaryHeavy drinking and alcohol use disorder are major public health problems. Practitioners not specialising in alcohol treatment are often unaware of the guidelines for preventing, identifying, and treating heavy drinking and alcohol use disorder. However, a consensus exists that clinically useful and valuable tools are available to address these issues. Here, we review existing information and developments from the past 5 years in these areas. We also include inform...