Re: Physical inactivity, cardiometabolic disease, and risk of dementia: an individual-participant meta-analysis - Authors ’ response
CONCLUSIONS: We highlight the frequent presence of amyloid pathology in prodromal LBD in our population, and the probable involvement of different metabolic pathways in the same clinically defined dementia. PMID: 31309997 [PubMed - in process]
Female military veterans with alcohol use disorder were three times more likely to develop dementia compared to their counterparts who did not engage in heavy alcohol use.Medscape Medical News
AbstractFrontotemporal dementia (FTD) is a highly heritable group of neurodegenerative disorders, with around 30% of patients having a strong family history. The majority of that heritability is accounted for by autosomal dominant mutations in the chromosome 9 open reading frame 72 (C9orf72), progranulin (GRN), and microtubule-associated protein tau (MAPT) genes, with mutations more rarely seen in a number of other genes. This review will discuss the recent updates in the field of genetic FTD. Age at symptom onset in genetic FTD is variable with recently identified genetic modifiers includingTMEM106B (inGRN carriers partic...
Manitoba Crown prosecutors are considering whether to lay criminal charges against a man in his 80s with dementia in the death of a 74-year-old woman at a Winnipeg personal care home.
CONCLUSIONS: Our findings imply a shared underlying pathology relating MS and brain volume and suggest cognitive functional declines through the muscle-brain axis. Further longitudinal studies are needed to find possible and related causes of reduced MS and cortical atrophy in patients with dementia. PMID: 31311027 [PubMed - as supplied by publisher]
CONCLUSIONS: The ACE-R s is sensitive, specific and reliable to detect dementia in persons aged ≥50 years in a Sinhala-speaking population and its diagnostic accuracy is superior to previously validated tools (MMSE and MoCA). PMID: 31311022 [PubMed - as supplied by publisher]
CONCLUSION: Our findings concur with previous research advocating that MCI is a heterogeneous concept, since the prevalence and incidence estimates differed substantially according to age, MCI subtype, and severity of cognitive impairment. PMID: 31311017 [PubMed - as supplied by publisher]
CONCLUSIONS: Reduction in Αβ42 in DLB may be more common (>80% of patients) than previously thought, and ∼40% may have the typical CSF AD biomarker profile. AD biochemistry in DLB may be an evolving process showing increasing frequency with disease progression. PMID: 31311013 [PubMed - as supplied by publisher]
(Korea Brain Research Institute) An international Research Team led by Dr. Jeong Yoon-ha at Korea Brain Research Institute has published the results of its research in 'Autophagy'. Expected to develop the treatment for neurodegenerative disease utilizing TDP-43 protein.
ConclusionThere was no evidence for a difference in dementia risk between AI and tamoxifen users among postmenopausal breast cancer survivors.Implications for Cancer SurvivorsOur findings suggest that there is no reason for concern about a difference in dementia risk with AI vs. tamoxifen, which is relevant to postmenopausal breast cancer patients recommended these treatments.