Preventing hepatitis C transmission from mothers to babies

(Joule Inc.) Hepatitis C virus (HCV) transmission from mothers to babies could largely be prevented if Canada recommended universal screening for HCV in pregnancy, argues a commentary in CMAJ (Canadian Medical Association Journal).
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news

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In conclusion, approximately 2% of pregnant women in the study population were known to have been exposed to HCV by the time of their delivery. One-third of women with documented drug abuse did not have an HCV test during pregnancy, revealing gaps in HCV testing of pregnant women. Further studies are needed to understand the full costs and benefits of risk-based screening versus universal screening in this and other populations. PMID: 31275902 [PubMed - in process]
Source: Canadian Journal of Gastroenterology - Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research
In a recent issue of Digestive and Liver Disease, Lembo et al. [1] presented an interesting survey on hepatitis B and hepatitis C prevalence in pregnancy in Southern Italy. Regarding hepatitis B virus (HBV), analyzing a cohort of 7,558 pregnant women, a prevalence of 0.5% was reported. Hepatitis B surface Antigen (HBsAg) seroprevalence was significantly higher among the 569 foreigners compared to the 5,559 Italian women (3% vs. 0.2%, p  
Source: Digestive and Liver Disease - Category: Gastroenterology Authors: Tags: Correspondence Source Type: research
CONCLUSIONS: HCV prevalence increased between 2007 and 2016, but screening and treatment of HCV in this southern obstetrical cohort was infrequent. The implementation of universal screening in pregnancy will likely identify additional cases, and an improved cascade of care will be necessary to address the HCV epidemic. PMID: 31158887 [PubMed - in process]
Source: Southern Medical Journal - Category: General Medicine Tags: South Med J Source Type: research
Authors: Luetkemeyer AF, Wyles DL Abstract At the 2019 Conference on Retroviruses and Opportunistic Infections (CROI), there was a major focus on hepatitis C virus (HCV) elimination and improving each component of the hepatitis C care cascade. Many interventions showed promising improvements in diagnosis and linkage to care. Settings with robust access to direct-acting antivirals (DAAs) continue to demonstrate the role of HCV treatment as prevention. However, substantial barriers to accessing curative therapy remain. Reinfection after treatment presents an important barrier to elimination, particularly in some popu...
Source: Topics in antiviral medicine - Category: Infectious Diseases Tags: Top Antivir Med Source Type: research
CONCLUSIONS: When managing pregnancy in referral hospitals in Latin America, it is important to discard liver alterations early for adequate follow up of the disease and to prevent adverse consequences for the mother and child. PMID: 31126882 [PubMed - as supplied by publisher]
Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
Authors: Shiha GE, El-Etreby S, Bahgat M, Hamed M, Sherbini ME, Ghoneem EA, Zalata K, Soliman RE, ElBasiouny MA, Mikhail NN Abstract INTRODUCTION AND AIM: Transient elastography is gaining popularity as a non-invasive method for predicting liver fibrosis, but inter observer agreement and factors influencing reproducibility have not been adequately assessed. MATERIAL AND METHODS: This cross-sectional study was conducted at Specialized Medical Hospital and the Egyptian Liver Foundation, Mansoura, Egypt. The inclusion criteria were: age older than 18 years and chronic infection by hepatitis C. The exclusion criter...
Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
AbstractPurpose of ReviewThe purpose of this review is to discuss the reasons for HCV testing during pregnancy and to review what is known about antiviral treatment during pregnancy.Recent FindingsHepatitis C virus affects over 3 million persons in the USA and is one of the leading infectious causes of death. While HCV is most commonly transmitted via parenteral exposures, thus affecting people who inject drugs, it is also transmitted from mother-to-child. Due to an expanding opioid crisis, an increasing number of women of childbearing age are now infected, resulting in transmission to infants. Risk-based screening has nev...
Source: Current Hepatitis Reports - Category: Infectious Diseases Source Type: research
Discussion MDSCs violently emerge in pathological conditions in an attempt to limit potentially harmful immune and inflammatory responses. Mechanisms supporting their expansion and survival are deeply investigated in cancer, in the perspective to reactivate specific antitumor responses and prevent their contribution to disease evolution. These findings will likely contribute to improve the targeting of MDSCs in anticancer immunotherapies, either alone or in combination with immune checkpoint inhibitors. New evidence indicates that the expansion of myeloid cell differentiation in pathology is subject to fine-tuning, as its...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Authors: Nolen LD, O'Malley JC, Seeman SS, Bruden DJT, Apostolou A, McMahon BJ, Bruce MG Abstract Recent reports have found a rise in Hepatitis C virus (HCV) infection in reproductive age women in the USA. Surveillance data suggests one group that is at increased risk of HCV infection is the American Indian and Alaska Native population (AI/AN). Using the National Center for Health Statistics (NCHS) birth certificate and the Indian Health Services, Tribal, and Urban Indian (IHS) databases, we evaluated reported cases of HCV infection in pregnant women between 2003 and 2015. In the NCHS database, 38 regions consisten...
Source: International Journal of Circumpolar Health - Category: International Medicine & Public Health Tags: Int J Circumpolar Health Source Type: research
We read with great interest Modin et al. in the November 2018 edition of Journal of Hepatology.1 Given the demonstrated long-term disease sequelae for children infected with hepatitis C virus (HCV) particularly through mother-to-child transmission (MTCT), we agree that there is a need for earlier detection and treatment of HCV in children. However, in the absence of universal guidelines for HCV screening during pregnancy, the antepartum case definition of HCV is inadequate, and coordination of maternal care is challenging.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research
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