Genetic diversity of HLA system in two populations from Sinaloa, Mexico: Culiac án and rural Sinaloa.

Genetic diversity of HLA system in two populations from Sinaloa, Mexico: Culiacán and rural Sinaloa. Hum Immunol. 2019 Jun 11;: Authors: Clayton S, Barquera R, Uribe-Duarte MG, Goné Vázquez I, Zúñiga J, Arrieta-Bolaños E, Hernández-Zaragoza DI, Ruíz-Corral MJ, Escobedo-Ruíz A, Arellano-Prado FP, García-Arias VE, Rodríguez-López ME, Bravo-Acevedo A, Sánchez-Fernández MGJ, Aguilar-Campos JA, Serrano-Osuna R, Gómez-Navarro B, Sandoval-Sandoval MJ, Yunis EJ, Bekker-Méndez C, Granados J Abstract We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 286 Mexicans from the state of Sinaloa living in Culiacán (N = 103) and rural communities (N = 183) to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes for the state of Sinaloa include ten Native American most probable ancestry and five European most probable ancestry haplotypes. The admixture estimates revealed that the main genetic components in the state of Sinaloa are European (62.39 ± 3.47%) and Native American (37.61 ± 2.85%), while the African genetic component was estimated as virtually absent (0.00 ± 1.86%). PMID: 31201081 [PubMed - as supplied by publisher]
Source: Human Immunology - Category: Allergy & Immunology Authors: Tags: Hum Immunol Source Type: research