Is the weight-reducing effect of aerobic exercise in mice mediated by a regulatory effect of SFRS10 on alternative splicing of PKCδI pre-mRNA?

Publication date: Available online 15 June 2019Source: Science &SportsAuthor(s): J. Zhao, J. Shi, B. Wu, X. Bai, H. DuSummaryIntroductionThe aim of this study was to determine the effects of aerobic exercise on the alternative splicing of PKCδI pre-mRNA in obese mice.Summary of facts and resultsAfter aerobic exercise, the weight, the Lee's index and the blood lipid levels of obese mice decreased significantly (P 
Source: Science and Sports - Category: Sports Medicine Source Type: research

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Abstract The main objective of this study was to identify the association between combined effect of physical activity, reduction of screen time and overweight in adolescents. The sample of this cross-sectional study consisted of 613 adolescents, aged 15-18 years living in a municipality in northeastern Brazil. Physical activity was measured using the short-version IPAQ (International Physical Activity Questionnaire), and screen time was verified through two questions about the time that, on average, interviewees watched television, played video games, used the cell phone or computer on a normal weekday and one weekend day...
Source: Revista Brasileira de Cineantropometria e Desempenho Humano - Category: Sports Medicine Source Type: research
The objective of this study was to correlate anthropometric, BIA and DXA parameters among obese Brazilian adults with focus on the comparison with visceral adipose tissue (VAT) obtained from DXA and in the value of antropometric measurements. Fifty voluntary participants were enrolled. The Spearman correlation test was used to assess the correlation of VAT with anthropometric measurements, BIA and other DXA parameters. The intra-class correlation coefficient (ICC) was used to evaluate concordance between lean mass (LM), fat mass (FM), %body fat (%BF) and %upper body fat (%UBF) obtained from BIA and DXA. Most were female (8...
Source: Revista Brasileira de Cineantropometria e Desempenho Humano - Category: Sports Medicine Source Type: research
This article aimed to systematically review the association between socioeconomic status according to the life course models and the body mass index (BMI) in adults. A review was performed following the guidelines of the PRISMA. The studies were identified in the MEDLINE/PubMed, LILACS and Web of Science databases. The eligible articles investigated the association between at least one life course model (risk accumulation, critical period or social mobility) and BMI. In order to assess the quality of the selected articles, the NOS checklist was applied to each study. Eleven articles were selected for the systematic review,...
Source: Cadernos de Saude Publica - Category: International Medicine & Public Health Authors: Tags: Cad Saude Publica Source Type: research
A systematic review was performed to investigate the impact of obesity on outcomes following total shoulder arthroplasty (TSA) and reverse total shoulder arthroplasty (RTSA).
Source: Journal of Shoulder and Elbow Surgery - Category: Orthopaedics Authors: Tags: Online Article Source Type: research
Journal Name: Journal of Pediatric Endocrinology and Metabolism Issue: Ahead of print
Source: Journal of Pediatric Endocrinology and Metabolism - Category: Endocrinology Source Type: research
Publication date: Available online 16 October 2019Source: Trends in Endocrinology &MetabolismAuthor(s): Niloy Iqbal, LIang Zhu, Streamson C. ChuaObesity is a neurological disorder that operates by favoring energy storage within adipose depots and increased caloric intake. Most cases of human obesity are acquired without any underlying genetic basis. Here, we suggest that obesity can impair the function of some hypothalamic neurons critical to body weight regulation. Genetic ablation of the retinoblastoma (Rb) gene within pro-opiomelanocortin (POMC) neurons leads to death of the neurons and subsequent obesity. The Rb pr...
Source: Trends in Endocrinology and Metabolism - Category: Endocrinology Source Type: research
This article provides a review of the preclinical and clinical pharmacology of lorcaserin, including its pharmacokinetic and safety profiles. Preclinical studies with lorcaserin initially focused on simple measures of food intake and body weight gain, but have now expanded to include studies on its effects on appetitive aspects of feeding behaviour and models of binge-eating. A significant number of studies have also shown that lorcaserin alters behaviours related to drug use and addiction, in rodents and non-human primates. Potential clinically-relevant effects of lorcaserin have also been reported in models of pain and s...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
The findings could explain why being overweight or obese increases asthma risk, researchers say.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
ConclusionsPressure-controlled ventilation mode is not superior to volume-controlled ventilation mode in patients with laparoscopic bariatric surgery.ResumoJustificativaO modo de ventilação mecânica que deve ser usado em cirurgia bariátrica, uma das opções de tratamento para pacientes com obesidade, ainda não foi definido.ObjetivosComparar as ventilações controladas por volume e por pressão em termos de mecânica respiratória e dos valores da gasometria arterial em pacientes submetidos à cirurgia bariátrica laparoscópica.M...
Source: Brazilian Journal of Anesthesiology - Category: Anesthesiology Source Type: research
People at high risk for serious flu complications are those with conditions such as asthma, chronic lung disease, diabetes, heart disease, morbid obesity, or adults aged 65 years or older.FDA Approvals
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Infectious Diseases News Alert Source Type: news
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