Impact of age on host responses to diet-induced obesity: Development of joint damage and metabolic set points

ConclusionThese findings indicate that the HFS Weanling group animals were better able to cope with the dietary challenge of an HFS diet than the HFS Adult group animals. Interestingly, when assessing various serum pro-inflammatory markers, no significant differences were detected between the HFS Adult and HFS Weanling groups. Although details regarding the mechanisms underlying an increase in knee joint damage scores in the HFS Adult group remain to be elucidated, these findings indicate that dietary exposure time maybe less important than the age at which a HFS diet is introduced. Moreover, increases in serum pro-inflammatory mediators do not appear to be directly linked to knee joint damage scores in the HFS Weanling group animals but may partly be responsible for the observed knee joint damage in the adults over the very short time of exposure to the HFS diet.Graphical abstract
Source: Journal of Sport and Health Science - Category: Sports Medicine Source Type: research