Histopathology of motor cortex in an experimental focal ischemic stroke in mouse model
In this study, focal cerebral ischemia was induced in mice by occlusion of the middle cerebral artery. We studied cortical layers I, II/III, V and VI in the caudal forelimb area (CFA) and medial agranular cortex (AGm) from control and C57BL/6 mice induced with ischemic stroke. Based on our analysis of CFA and AGm motor cortex, significant differences were observed in the numbers of neurons, astrocytes and microglia in the superficial II/III and deep V cortical layers. Cellular changes were more prominent in layer V of the CFA with nuclear pyknosis, chromatin fragmentation, necrosis and degeneration, as well as, morphological evidence of apoptosis, mainly in neurons. As result, the CFA was more severely impaired than the AGm in this focal cerebral ischemic model, as evidenced by the proliferation of astrocytes, potentially resulting in neuroinflammation by microglia-like cells.
This cohort study investigates whether procedural blood pressure parameters, including specific blood pressure thresholds, are associated with neurological outcomes after endovascular therapy.
This case report describes a 65-year-old woman with a right-hemispheric ischemic stroke in the territory of the middle cerebral artery along with left-sided hemiparesis with dysarthria and left-sided visual hemineglect.
Current guidelines preclude the administration of intravenous tissue plasminogen activator in patients with early recurrent stroke (prior ischemic stroke within three months).
Publication date: Available online 25 January 2020Source: Journal of Clinical NeuroscienceAuthor(s): Juliane Herm, Alexander Schirdewan, Lydia Koch, Alexander Wutzler, Jochen B. Fiebach, Matthias Endres, Ute A. Kopp, Karl Georg HaeuslerAbstractAtrial fibrillation (AF) is associated with cognitive decline and dementia irrespective of AF-related ischemic stroke. We investigated whether AF burden after ablation in patients with symptomatic paroxysmal AF has an impact on cognitive function. After enrolment to the prospective MACPAF study, study patients received an insertable loop recorder (ILR) and underwent serial neurologic...
Publication date: Available online 25 January 2020Source: Clinica Chimica ActaAuthor(s): Guo-Hai Zhang, Zhe-Hao Ye, Hao-Jie Guan, Mi Guo, Xin-Xiang Zhou, Yu-Yu XuAbstractBackgroundReduced serum omentin-1 concentrations might be related to an increased risk for poor functional outcome after acute ischemic stroke. We intended to explore whether serum omentin-1 could be a promising prognostic biomarker for acute intracerebral hemorrhage.MethodsA total of 104 consecutive patients with hemorrhagic stroke underwent 90-day follow-up. The modified Rankin scale score> 2 was evaluated as worse prognosis. A multivariable logistic ...
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CONCLUSION: HFpEF confers a significant perioperative risk of MACCE in patients undergoing hip fracture surgery. PMID: 31977615 [PubMed - in process]
CONCLUSION: This paper provides a new hybrid GSA-RDF classifier technique to segment the ischemic stroke lesions in MR images. The experimental results demonstrate that the proposed technique has the Root Mean Square Error (RMSE), Mean Absolute Percentage Error (MAPE), and Mean Bias Error (MBE) ranges are 16.5485 %, 7.2654 %, and 2.4585 %individually. The proposed RDF-GSA algorithm has better precision and execution when compared with the existing ischemic stroke segmentation method. PMID: 31975663 [PubMed - in process]
CONCLUSION: As reimbursement for emergency medicine in Germany was recently rearranged, quality benchmarking has gained incremental importance. Mandatory joint quality measurement in both concepts ensuring gap analysis and process improvement is encouraged. PMID: 31970463 [PubMed - as supplied by publisher]
ConclusionAbout two third of the patients had poor treatment outcome. Educational status and mean length of hospital stays were independent predictors of poor treatment out-comes. An emergency care setup capable of early patient evaluation, identification and management of stroke complications is crucial to overcome early stroke related mortality.