Probiotic consumption during puberty mitigates LPS-induced immune responses and protects against stress-induced depression- and anxiety-like behaviors in adulthood in a sex-specific manner

Publication date: Available online 15 June 2019Source: Brain, Behavior, and ImmunityAuthor(s): Emma Murray, Rupali Sharma, Kevin Smith, Kendall Mar, Rudra Barve, Matthew Lukasik, Atiqa Pirwani, Etienne Malette-Guyon, Sanjeevani Lamba, Bronwen Thomas, Homa Sadeghi-Emamchaie, Jacky Liang, Jean-François Mallet, Chantal Matar, Nafissa IsmailAbstractPuberty/adolescence is a significant period of development and a time with a high emergence of psychiatric disorders. During this period, there is increased neuroplasticity and heightened vulnerability to stress and inflammation. The gut microbiome regulates stress and inflammatory responses and can alter brain chemistry and behaviour. However, the role of the gut microbiota during pubertal development remains largely uninvestigated. The current study examined gut manipulation with probiotics during puberty in CD1 mice on lipopolysaccharide (LPS)-induced immune responses and enduring effects on anxiety- and depression-like behaviours and stress-reactivity in adulthood. Probiotics reduced LPS-induced sickness behaviour at 12 hours in females and at 48 hours following LPS treatment in males. Probiotics also reduced LPS-induced changes in body weight at 48 hours post-treatment in females. Probiotic treatment also prevented LPS-induced increases in pro- and anti-inflammatory peripheral cytokines at 8 hours following LPS treatment, reduced central cytokine mRNA expression in the hypothalamus, hippocampus and PFC, and prevented LPS-induced ...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research