Method for Stimulation of Hippocampal Neurogenesis by Transient Microneedle Insertion.
Method for Stimulation of Hippocampal Neurogenesis by Transient Microneedle Insertion.
Methods Mol Biol. 2019;1919:227-235
Authors: Song S, Kong X, Sanchez-Ramos J
Abstract
Brief stereotaxic insertion and removal of a microneedle into the hippocampus of mice result in stimulation of hippocampal neurogenesis. This approach has been previously applied to a mouse model of Alzheimer's disease (Song et al., Cell Transplant 25:1853-1861, 2016). Further studies of fundamental cellular mechanisms of the brain's response to micro-injury will be useful for investigation of potential neuroprotective and deleterious effects of targeted microlesions and deep brain stimulation in neurodegenerative diseases.
PMID: 30656634 [PubMed - indexed for MEDLINE]
Source: Mol Biol Cell - Category: Molecular Biology Authors: Song S, Kong X, Sanchez-Ramos J Tags: Methods Mol Biol Source Type: research
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