Corticotropin-Releasing Factor (CRF) Circuit Modulation of Cognition and Motivation

Publication date: Available online 15 June 2019Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Sofiya Hupalo, Courtney A. Bryce, Debra A. Bangasser, Craig W. Berridge, Rita J. Valentino, Stan B. FlorescoAbstractThe neuropeptide, corticotropin-releasing factor (CRF), is a key modulator of physiological, endocrine, and behavioral responses during stress. Dysfunction of the CRF system has been observed in stress-related affective disorders including post-traumatic stress disorder, depression, and anxiety. Beyond affective symptoms, these disorders are also characterized by impaired cognition, for which current pharmacological treatments are lacking. Thus, there is a need for pro-cognitive treatments to improve quality of life for individuals suffering from mental illness. In this review, we highlight research demonstrating that CRF elicits potent modulatory effects on higher-order cognition via actions within the prefrontal cortex and subcortical monoaminergic and cholinergic systems. Additionally, we identify questions for future preclinical research on this topic, such as the need to investigate sex differences in the cognitive and microcircuit actions of CRF, and whether CRF may represent a pharmacological target to treat cognitive dysfunction. Addressing these questions will provide new insight into pathophysiology underlying cognitive dysfunction and may lead to improved treatments for neuropsychiatric disorders.
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research

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Source: The American Journal of Orthopsychiatry - Category: Psychiatry Tags: Am J Orthopsychiatry Source Type: research
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Source: JAMA - Category: General Medicine Source Type: research
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Source: JAMA - Category: General Medicine Source Type: research
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Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Health & Wellness Technology brain health digital mental health Dolby Family Ventures Merck Ventures Mindstrong Health NeuraMetrix Rethinking retooling University-of-Michigan Source Type: blogs
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Source: Journal of Vestibular Research: Equilibrium and Orientation - Category: Neuroscience Tags: J Vestib Res Source Type: research
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Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
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Source: Trials - Category: Research Source Type: clinical trials
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Source: Aging and Mental Health - Category: Geriatrics Authors: Tags: Aging Ment Health Source Type: research
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