Natural Terpenoids as Neuroinflammatory Inhibitors in LPS-stimulated BV-2 Microglia.

Natural Terpenoids as Neuroinflammatory Inhibitors in LPS-stimulated BV-2 Microglia.
Mini Rev Med Chem. 2019 Jun 11;:
Authors: Xu Y, Wei H, Gao J
Abstract
BACKGROUND: Neuroinflammation is a typical feature of many neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Microglia, the resident immune cells of the brain, readily become activated in response to infection or injury. Uncontrolled and overactivated microglia can release pro-inflammatory and cytotoxic factors and are the major culprit in neuroinflammation. Hence, research into novel neuroinflammatory inhibitors is of paramount importance for the treatment of neurodegenerative diseases. Bacterial lipopolysaccharide, widely used in studies of brain inflammation, initiates several major cellular activities that critically contribute to the pathogenesis of neuroinflammation.
OBJECTIVE: This review will highlight the progress on terpenoids, an important and structurally diverse group of natural compounds, as neuroinflammatory inhibitors in lipopolysaccharide-stimulated BV-2 microglial cells over the last 20 years.
PMID: 31198113 [PubMed - as supplied by publisher]

Source: Mini Reviews in Medicinal Chemistry - June 10, 2019 Category: Chemistry Authors: Xu Y, Wei H, Gao J Tags: Mini Rev Med Chem Source Type: research