Distribution of locoregional breast cancer recurrence in relation to postoperative radiation fields and biological subtypes

The pattern of locoregional recurrence (LRR) in relation to postoperative locoregional radiotherapy and primary breast cancer biology has been analysed. The 10 year cumulative incidence of LRR was 7.1%. Most LRR developed within the irradiated volume, while the most common location for out-of-field LRR was the cranial supraclavicular fossa. A higher LRR frequency was observed in ER- and/or HER2+ breast cancer. In addition, ER-/Her2+ tumours more frequently recurred in-field (68%) rather than marginal/out-of-field (32%).
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research