Same-stage total knee arthroplasty and osteotomy for osteoarthritis with extra-articular deformity. Part I: Tibial osteotomy, prospective study of 26 cases

The objective of this study was to assess outcomes in 26 patients managed with 1S-TKA-TO.Hypothesis1S-TKA-TO produces satisfactory clinical and anatomical outcomes and is not associated with higher morbidity rates compared to TKA alone or two-stage TKA-TO.Material and methodsA prospective study was conducted in 25 patients (26 knees) managed with 1S-TKA-TO between 1995 and 2014. There were 16 males and 9 females with a mean age of 64 years (range, 29–80 years) and a mean body mass index of 29.6 (range, 24–49). The EKD was constitutional in 14 knees, post-traumatic in 5 knees, and induced by TO in 7 knees. None of the patients received a hinged knee implant. In each patient, the clinical International Knee Society (IKS score) was assessed and the hip-knee-ankle angle (HKA), tibial mechanical angle (TMA), and femoral mechanical angle (FMA) were measured on radiographs before surgery and at last follow-up.ResultsThe mean IKS score increased significantly, from 70 before surgery to 170 at the end of the mean 9-year follow-up. Mean flexion range increased from 98° to 107°. The clinical and anatomical outcomes were satisfactory in 25 patients. In the remaining patient, who had a history of multiple surgeries for Blount disease and a body mass index of 49, a severe complication consisting in massive skin necrosis followed by infection occurred; this was the only patient who required revision surgery with implant removal.DiscussionThese findings are consistent wit...
Source: Orthopaedics and Traumatology: Surgery and Research - Category: Orthopaedics Source Type: research

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Platelet-rich plasma (PRP) is an emerging therapeutic strategy for treatment of osteoarthritis (OA); however, there is a lack of preclinical and clinical evidence for its efficacy and its mechanism of action is unclear. In the current study, we utilized leukocyte poor-PRP (LP-PRP) and leukocyte rich-PRP (LR-PRP) to mimic clinical point of care formulations and assessed their potential to alter disease progression in a mouse model of post-traumatic OA.
Source: Osteoarthritis and Cartilage - Category: Rheumatology Authors: Source Type: research
DiscussionThe results of the gait analysis from the current study will help to impartially and reliably evaluate the clinical and biomechanical outcome of both treatment options of acute syndesmosis ruptures. We hypothesize that the dynamic fixation provides an equivalent or better biomechanical, clinical, and radiographic outcome in comparison to the screw fixation.Trial registrationGerman Clinical Trials Register (DRKS)DRKS00013562. Registered on July, 12, 2017.
Source: Trials - Category: Research Source Type: clinical trials
AbstractPurposeAcetabular fractures are accompanied by complications such as post-traumatic osteoarthritis (OA) of the hip and avascular necrosis (AVN) of the femoral head. The aim of the study was to evaluate improvement of life quality and functional recovery after total hip arthroplasty (THA) in patients with post-traumatic OA and AVN.MethodsWe retrospectively reviewed 23 patients with post-traumatic OA of the hip and AVN of the femoral head who undergone THA, out of 63 patients who were previously surgically treated for acetabular fractures. Final functional outcomes are defined according to the Merle d ╩╝Aubigné...
Source: International Orthopaedics - Category: Orthopaedics Source Type: research
In this study, we examined the ability of the senolytic drug ABT263 (navitoclax) to clear SnCs and further evaluated the therapeutic effect of ABT263 on post-traumatic OA. Monolayer and 3D pellet cultured osteoarthritic chondrocytes were used to evaluate the effect of ABT263 in vitro and a DMM rat model was established for in vivo experiments. We found that ABT263 reduced the expression of inflammatory cytokines and promoted cartilage matrix aggregation in OA chondrocyte pellet culture by inducing SnC apoptosis. Moreover, OA pathological changes in the cartilage and subchondral bone in post-traumatic OA rat were alleviated...
Source: Aging - Category: Biomedical Science Authors: Tags: Aging (Albany NY) Source Type: research
Authors: de Campos GC, Tieppo AM, de Almeida CS, Hamdan PC, Alves WM, de Rezende MU Abstract There is still no definitive treatment for knee osteoarthritis (OA). We are certainly far from a consensus on the best form of treatment or on an effective treatment recommendation. There are reasons for the current equivocal treatment recommendations in the face of this very serious health problem. The greatest of these reasons, undoubtedly, is the great complexity of the factors involved in the development and progression of knee OA and the complex pathophysiology including mechanical, inflammatory, metabolic, post-trauma...
Source: World Journal of Orthopaedics - Category: Orthopaedics Tags: World J Orthop Source Type: research
by Atte S. A. Eskelinen, Petri Tanska, Cristina Florea, Gustavo A. Orozco, Petro Julkunen, Alan J. Grodzinsky, Rami K. Korhonen Post-traumatic osteoarthritis (PTOA) is associated with cartilage degradation, ultimately leading to disability and decrease of quality of life. Two key mechanisms have been suggested to occur in PTOA: tissue inflammation and abnormal biomechanical loading. Both mechanisms have been suggested to r esult in loss of cartilage proteoglycans, the source of tissue fixed charge density (FCD). In order to predict the simultaneous effect of these degrading mechanisms on FCD content, a computational model...
Source: PLoS Computational Biology - Category: Biology Authors: Source Type: research
AbstractPurposeWe asked whether the clinical and radiographic outcomes and survivorship after unicompartmental knee arthroplasty (UKA) for osteoarthritis (OA) consequent to lateral tibial plateau fracture were comparable with those obtained after lateral UKA for primary OA.MethodsA total of 13 patients receiving lateral UKA for OA secondary to tibial plateau fracture (post-traumatic UKA, P-UKA) were compared with 13 patients who underwent lateral UKA for primary OA (OA-UKA). Patients were matched for age at surgery, gender, body mass index, and follow-up length. Pre- and post-operative clinical and radiographic assessments...
Source: International Orthopaedics - Category: Orthopaedics Source Type: research
Rouhani Lower extremity kinematic alterations associated with sport-related knee injuries may contribute to an unsuccessful return to sport or early-onset post-traumatic osteoarthritis. Also, without access to sophisticated motion-capture systems, temporospatial monitoring of horizontal hop tests during clinical assessments is limited. By applying an alternative measurement system of two inertial measurement units (IMUs) per limb, we obtained and validated flying/landing times and hop distances of triple single-leg hop (TSLH) test against motion-capture cameras, assessed these temporospatial parameters amongst injured ...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
Abstract Purpose: To cross-cultural translate the Cumberland Ankle Instability Tool (CAIT) to Taiwan-Chinese version (CAIT-TW), and to evaluate the validity, reliability and cutoff score of CAIT-TW for Taiwan-Chinese athletic population.Materials and methods: The English version of CAIT was translated to CAIT-TW based on a guideline of cross-cultural adaptation. 77 and 58 Taiwanese collegial athletes with and without chronic ankle instability filled out CAIT-TW, Taiwan-Chinese version of Lower Extremity Functional Score (LEFS-TW) and Numeric Rating Scale (NRS). The construct validity, test-retest reliability, inte...
Source: Disability and Rehabilitation - Category: Rehabilitation Authors: Tags: Disabil Rehabil Source Type: research
Since the introduction of modern total elbow arthroplasty (TEA), there has been a rapid evolution in the understanding of elbow biomechanics, surgical techniques, and improvements in implant materials and design. Aimed originally to treat primarily end-stage rheumatoid arthritis, the indications for TEA have extended to include post-traumatic arthritis, primary osteoarthritis and acute non-reconstructable fractures of the distal humerus. Implant survivorship in TEA is substantially longer in patients with inflammatory arthritis when compared to trauma-related indications.
Source: Orthopaedics and Trauma - Category: Orthopaedics Authors: Source Type: research
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