Same-stage total knee arthroplasty and osteotomy for osteoarthritis with extra-articular deformity. Part I: Tibial osteotomy, prospective study of 26 cases

The objective of this study was to assess outcomes in 26 patients managed with 1S-TKA-TO.Hypothesis1S-TKA-TO produces satisfactory clinical and anatomical outcomes and is not associated with higher morbidity rates compared to TKA alone or two-stage TKA-TO.Material and methodsA prospective study was conducted in 25 patients (26 knees) managed with 1S-TKA-TO between 1995 and 2014. There were 16 males and 9 females with a mean age of 64 years (range, 29–80 years) and a mean body mass index of 29.6 (range, 24–49). The EKD was constitutional in 14 knees, post-traumatic in 5 knees, and induced by TO in 7 knees. None of the patients received a hinged knee implant. In each patient, the clinical International Knee Society (IKS score) was assessed and the hip-knee-ankle angle (HKA), tibial mechanical angle (TMA), and femoral mechanical angle (FMA) were measured on radiographs before surgery and at last follow-up.ResultsThe mean IKS score increased significantly, from 70 before surgery to 170 at the end of the mean 9-year follow-up. Mean flexion range increased from 98° to 107°. The clinical and anatomical outcomes were satisfactory in 25 patients. In the remaining patient, who had a history of multiple surgeries for Blount disease and a body mass index of 49, a severe complication consisting in massive skin necrosis followed by infection occurred; this was the only patient who required revision surgery with implant removal.DiscussionThese findings are consistent wit...
Source: Orthopaedics and Traumatology: Surgery and Research - Category: Orthopaedics Source Type: research

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Contributors : Ren Xiaoqing ; Hu BoqiangSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : Homo sapiensChromobox homolog 4 (CBX4), a component of polycomb repressive complexes 1 (PRC1), plays important roles in the maintenance of cell identity and organism development through epigenetic silencing. However, it remains unclear whether CBX4 regulates the homeostasis of human stem cells. Here, we demonstrate that CBX4 counteracts human mesenchymal stem cell (hMSC) aging via the maintenance of nucleolar homeostasis. CBX4 protein d...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Other Homo sapiens Source Type: research
DiscussionFindings will provide patients with better information about the potential benefits and harms of stemless and stemmed TSA and will assist shoulder surgeons and patients in decision-making.Trial registrationClinicaltrials.gov,NCT03877315. Registered on 13 March 2019.
Source: Trials - Category: Research Source Type: clinical trials
Following publication of the original article [1], the authors opted to correct the middle initial of co-author Despina N. Perrea from S to N. The original article has been corrected.
Source: Journal of Experimental Orthopaedics - Category: Orthopaedics Authors: Tags: Correction Source Type: research
“Synergy” is the interaction of two or more factors to produce a combined outcome greater than the sum of their individual effects. It is interesting to consider synergism in the context of osteoarthritis (OA) as a “whole-joint disease”, and how...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Joint injury involving destabilisation of the joint and damage to the articular cartilage (e.g. sports-related injury) can result in accelerated post-traumatic osteoarthritis (PTOA). Destabilised medial meniscotibial ligament (DMM) surgery is one of the most commonly used murine models and whilst it recapitulates OA pathology, it does not necessarily result in multi-tissue injury, as occurs in PTOA. We hypothesised that simultaneous cartilage damage and joint destabilisation would accelerate the onset of OA pathology.
Source: Osteoarthritis and Cartilage - Category: Rheumatology Authors: Source Type: research
“Synergy” is the interaction of two or more factors to produce a combined outcome greater than the sum of their individual effects. It is interesting to consider synergism in the context of osteoarthritis (OA) as a “whole-joint disease”, and how the combination of individual events or risk-f actors that contribute to OA initiation and/or progression, may have more than just additive effects on joint-wide OA pathology and its systemic symptomatic consequences. This idea is highlighted in an interesting paper by McCulloch et al in the current issue (REF####), where the authors studied the effect of co...
Source: Osteoarthritis and Cartilage - Category: Rheumatology Authors: Tags: Editorial Source Type: research
To investigate the potential of quantitative susceptibility mapping (QSM) and T2* relaxation time mapping to determine mechanical and structural properties of articular cartilage via univariate and multivariate analysis.
Source: Osteoarthritis and Cartilage - Category: Rheumatology Authors: Source Type: research
Mechanical loading and joint health have a unique relationship in osteoarthritis (OA) onset and progression. Although high load levels adversely affect cartilage health, exercise that involves low to moderate load levels can alleviate OA symptoms. We sought to isolate the beneficial effects of mechanical loading using controlled in vivo cyclic tibial compression. We hypothesized that low-level cyclic compression would attenuate post-traumatic OA symptoms induced by destabilization of the medial meniscus (DMM).
Source: Osteoarthritis and Cartilage - Category: Rheumatology Authors: Source Type: research
Authors: Khlopas H, Khlopas A, Samuel LT, Ohliger E, Sultan AA, Chughtai M, Mont MA Abstract Ankle osteoarthritis constitutes a large burden to society and is a leading cause of chronic disability in the United States. Most commonly, it is post-traumatic, occurs in younger individuals, and is associated with obesity. This entity presents similarly to osteoarthritis of the other joints, with the typical nonspecific symptoms of stiffness, swelling, and pain. Radiographic investigation includes four weight-bearing standard views: antero-posterior and lateral foot, mortise view of the ankle, and a specialized view of t...
Source: Surgical Technology International - Category: Surgery Tags: Surg Technol Int Source Type: research
The purpose of this study is to investigate the possible attenuating role of the intra-articular administration of Fetuin-A in post-traumatic secondary osteoarthritis in rats, and also its effect on the system...
Source: Journal of Experimental Orthopaedics - Category: Orthopaedics Authors: Tags: Research Source Type: research
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