Cellular and regional vulnerability in frontotemporal tauopathies

AbstractThe frontotemporal tauopathies all deposit abnormal tau protein aggregates, but often of only certain isoforms and in distinguishing pathologies of five main types (neuronal Pick bodies, neurofibrillary tangles, astrocytic plaques, tufted astrocytes, globular glial inclusions and argyrophilic grains). In those with isoform specific tau aggregates glial pathologies are substantial, even though there is limited evidence that these cells normally produce tau protein. This review will assess the differentiating features and clinicopathological correlations of the frontotemporal tauopathies, the genetic predisposition for these different pathologies, their neuroanatomical selectivity, current observations on how they spread through the brain, and any potential contributing cellular and molecular changes. The findings show that diverse clinical phenotypes relate most to the brain region degenerating rather than the type of pathology involved, that different regions on theMAPT gene and novel risk genes are associated with specific tau pathologies, that the 4-repeat glial tauopathies do not follow individual patterns of spreading as identified for neuronal pathologies, and that genetic and pathological data indicate that neuroinflammatory mechanisms are involved. Each pathological frontotemporal tauopathy subtype with their distinct pathological features differ substantially in the cell type affected, morphology, biochemical and anatomical distribution of inclusions, a fundam...
Source: Acta Neuropathologica - Category: Neurology Source Type: research

Related Links:

Source: Revista Brasileira de Saude Materno Infantil - Category: Midwifery Source Type: research
Conclusions: WISC-III evaluated the cognitive performance in children, born preterm, aged 6-8 years old, and had neonatal ICH did not differ from those of their peers without a history of ICH. These findings suggest that, in preterm infants, a neonatal diagnosis of ICH may not be associated with cognitive performance at school age and this should be investigated through a longitudinal study.Resumo Objetivos: comparar o desempenho cognitivo de escolares, nascidos prematuramente, segundo a presen ça de hemorragia intracraniana (HIC) no período neonatal. Métodos: corte transversal de uma coorte de escolar...
Source: Revista Brasileira de Saude Materno Infantil - Category: Midwifery Source Type: research
Conclusions: Pregnancy planning and women's satisfaction with the discovery of being pregnant favors the performance of prenatal care with better indicators.Resumo Objetivos: analisar a influ ência do planejamento reprodutivo e da satisfação das mulheres com a descoberta da gravidez nas características da assistência pré-natal. Métodos: estudo transversal e quantitativo realizado entre março e julho de 2018 em uma maternidade de risco habitual no Nordeste brasileiro. Foram avali adas 652 puérperas por meio de entrevista e visualização do cartã...
Source: Revista Brasileira de Saude Materno Infantil - Category: Midwifery Source Type: research
Conclusions: in a retrospective application of the use of MEOWS showed a significant number of patients had triggered in which the nursing team did not recognize 99.2% of cases. This finding could be attributed to the fact that MEOWS has not been yet adopted in this service as part of the nursing care. The application of this tool would result in a better care because critical situations would be recognized and corrected quickly, avoiding unfavorable outcomes.Resumo Objetivos: avaliar o modified early obstetric warning system (MEOWS) em mulheres ap ós gestações, em um hospital terciário do Brasi...
Source: Revista Brasileira de Saude Materno Infantil - Category: Midwifery Source Type: research
Conclusions: it was possible to recognize doula as part of the humanized care, to provide subsidies for a reflection of her work, and to reveal the influence of the practice of doulagem for academic formation of doulas at university.Resumo Objetivos: analisar a compreens ão das puérperas, das doulas e da equipe assistencial sobre a presença da doula durante o processo de parturição das gestantes. Métodos: trata-se de estudo qualitativo, utilizando como instrumento de coleta de dados entrevistas semiestruturadas. O critério de saturação foi utilizado para l imit...
Source: Revista Brasileira de Saude Materno Infantil - Category: Midwifery Source Type: research
Conclusions: greater adherence to the “ Brazilian traditional ” and “ healthy ” dietary patterns was inversely associated with feelings of depression during pregnancy, possibly mediated by the degree of industrial processing of the foods.Resumo Objetivos: investigar a rela ção entre padrões alimentares e o grau de processamento de alimentos com sentimento de depressão na gestação. Métodos: estudo transversal conduzido entre 784 gestantes adultas de Ribeirão Preto, SP, em 2011-2012. O sentimento de depressão foi obtido por questioná...
Source: Revista Brasileira de Saude Materno Infantil - Category: Midwifery Source Type: research
Conclusions: When compared with adolescent women, pregnant women of advanced age presented a higher frequency of cesarean deliveries.Resumo Objetivos: comparar os resultados perinatais adversos em gesta ções de adolescentes e mulheres em idade avançada de rede pública de saúde. Métodos: estudo transversal realizado com gestantes nos extremos de idade reprodutiva segundo classificação do Ministério da Saúde do Brasil (adolescentes aquelas com idade ≤ 19 anos e em idade avan çada aquelas com idade ≥ 35 anos) e seus rec ém-nascidos. Fora...
Source: Revista Brasileira de Saude Materno Infantil - Category: Midwifery Source Type: research
Abstract Objectives: To investigate full term newborns suction pattern in non-nutritive suction and their feeding performance. Methods: An analytical descriptive study was carried out from November 2016 to March 2017, with 50 dyads mothers/newborns through the non-nutritive suction evaluation and a direct observation on the newborn's performance on feeding. The data were distributed through simple and relative frequencies (percentages) when categorical or by mean, maximum, minimum and the standard deviation when is continuous, discrete or ordinal. To evaluate the mean differences, the Student's t test was used with signifi...
Source: Revista Brasileira de Saude Materno Infantil - Category: Midwifery Source Type: research
Conclusions: the factors associated with cervical adenocarcinoma were ≥ 40 years old, ≤ 3 years of schooling, black race, menopausal status, never had undergone cervical cancer screening and the presence of HPV.Resumo Objetivos: determinar a incid ência dos principais Papilomavirus Humano (HPV) de alto risco oncogênico (16, 18, 31 e 33) e os fatores associados ao adenocarcinoma do colo uterino. Métodos: realizado estudo de caso-controle com 324 mulheres (69 com adenocarcinoma e 260 controles saudáveis), de 2001 a 2014. Foram colhidas inf ormações sobre fatores de risco associad...
Source: Revista Brasileira de Saude Materno Infantil - Category: Midwifery Source Type: research
Conclusions: the prevalence found was higher than that of other national researches, especially for the female gender. In the male gender, not having internet access, a lesser number of family members and a longer screen time proved to be factors associated with being excess weight.Resumo Objetivos: investigar a preval ência de excesso de peso e fatores associados entre adolescentes de uma comunidade de baixa renda situada na cidade do Recife, Pernambuco. Métodos: estudo transversal, em que foram coletadas informações demográficas, socioeconômicas e comportamentais no período ...
Source: Revista Brasileira de Saude Materno Infantil - Category: Midwifery Source Type: research
More News: Brain | Genetics | Neurology | Pathology