Host poly(ADP-ribose) polymerases (PARPs) in acute and chronic bacterial infections

Publication date: Available online 15 June 2019Source: Microbes and InfectionAuthor(s): Moona Miettinen, Madhukar Vedantham, Arto T. PulliainenAbstractProtein ADP-ribosylation is a reversible post-translational modification, which alters protein activity, localization, interactome or stability, leading to perturbation of cell signaling. This review summarizes the emerging data indicating that host cell ADP-ribosylating enzymes, poly(ADP-ribose) polymerases (PARPs), influence the course of a bacterial infection, in parallel to ADP-ribosylating bacterial toxins. Host cell PARP targeting could be an efficient therapeutic approach to treat certain bacterial infections, possibly by repurposing the approved or clinical trial PARP inhibitors developed for cancer therapy.
Source: Microbes and Infection - Category: Infectious Diseases Source Type: research