Angiotensin II acutely increases arterial stiffness as monitored by cardio-ankle vascular index (CAVI) in anesthetized rabbits

Publication date: Available online 15 June 2019Source: Journal of Pharmacological SciencesAuthor(s): Kiyoshi Sakuma, Akira Shimoda, Hiroaki Shiratori, Tetsuya Komatsu, Kento Watanabe, Tatsuo Chiba, Megumi Aimoto, Yoshinobu Nagasawa, Yuichi Hori, Kohji Shirai, Akira TakaharaAbstractThe cardio-ankle vascular index (CAVI) has been established as a stiffness indicator from thoracic aorta to tibial arteries. To better understand physiological regulatory factors for the arterial stiffness, we assessed effects of angiotensin II and adrenaline on the CAVI in anesthetized rabbits. A hypertensive dose of angiotensin II (300 ng/kg, i.v.) increased the CAVI as well as the heart-ankle pulse wave velocity (haPWV). On the other hand, although a hypertensive dose of adrenaline (1000 ng/kg, i.v.) increased the haPWV, it did not affect the CAVI. These results suggest that angiotensin II may act as a regulatory factor for arterial stiffness.
Source: Journal of Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research