Next generation sequencing identifies the keratinocyte-specific miRNA signature of psoriasis

Psoriasis is the most common immune-mediated skin disease in adults (Lowes et al., 2014), in which the disturbed interplay between keratinocytes and immune cells leads to chronic skin inflammation (Lowes et al., 2014). Conventionally, keratinocytes were thought to be passive bystanders, however recent research suggests their active involvement in the disease (Lowes et al., 2014, Swindell et al., 2011). In psoriasis, keratinocytes acts as an amplifier of skin inflammation by producing antimicrobial peptides, cytokines and chemokines (Lowes et al., 2014).

Source: Journal of Investigative Dermatology - June 14, 2019 Category: Dermatology Authors: Ankit Srivastava, Florian Meisgen, Lorenzo Pasquali, Sara Munkhammar, Ping Xia, Mona St åhle, Ning Xu Landén, Andor Pivarcsi, Enikö Sonkoly Tags: Letters to the Editor Source Type: research