Depression and Temporal Lobe Epilepsy: Expression Pattern of Calbindin Immunoreactivity in Hippocampal Dentate Gyrus of Patients Who Underwent Epilepsy Surgery with and without Comorbid Depression.

Conclusions: In this exploratory study, comorbid depression was associated with a differential pattern of CB cell loss in dentate gyrus combined with a higher CB sprouting. These changes may indicate granular cell dysmaturation associated to the epileptic hyperexcitability phenomena. Further investigations should be carried out to confirm these preliminary findings.
PMID: 31191739 [PubMed - in process]

Source: Behavioural Neurology - June 15, 2019 Category: Neurology Authors: D'Alessio L, Konopka H, Solís P, Scévola L, Lima MF, Nuñez C, Seoane E, Oddo S, Kochen S Tags: Behav Neurol Source Type: research