Cytogenetic profile of a representative cohort of young adults with de novo Acute Myéloblastic Leukaemia in Morocco

Publication date: Available online 15 June 2019Source: Cancer GeneticsAuthor(s): Nisrine Khoubila, Mounia Bendari, Nezha Hda, Mouna Lamchahab, Meryem Qachouh, Mohamed Rachid, Asmaa QuessarSummaryBackgroundWe analyzed the cytogenetic characteristics of a representative population of young adults with de novo acute myeloblastic leukemia (AML) treated in a single center institution.MethodsPatients with de novo AML included were aged between 20 and 60 years. Cytogenetic analysis was done at diagnosis. Twenty cells were analyzed, although examination of lower numbers of metaphases was also acceptable if an abnormal clone was detected.FindingsFrom 1/1/04 to 31/12/2014, among 1315 adult patients, 1055 (80%) patients were aged between 20 and 60 years. Karyotype was done in 927 (88%) patients and cytogenetic analysis failed in 32 cases (3•4%). Clonal abnormalities were observed in 520 (58%) patients. 175 (19•5%) were classified in the favorable group, 609 were in the intermediate group and 111 (12•5%) were in the adverse group. The most frequent chromosomal abnormality observed was t(8;21) in 112 (12•5%). Thirty three (3•7%) patients had t(15;17) and 30 (3•3%) had inv16, trisomy 8 was found in 47 (5•2%), 11q23 rearrangements in 32 (3•6%), 67 (7•4%) had a complex karyotype, -5/del(5q) and -7/del(7q) were seen in respectively 11(1%) and 27 (3%). Monosomy occurred in 115 (13%) patients, 70 (8%) responded to the definition of monosomal karyotypes.InterpretationThis is th...
Source: Cancer Genetics - Category: Cancer & Oncology Source Type: research