Dexfenfluramin: a forgotten cause of aortic stenosis.
Dexfenfluramin: a forgotten cause of aortic stenosis. Acta Cardiol. 2019 Jun 14;:1-2 Authors: Malergue MC, Ohanessian A, Zannis K, Bruneval P, Ennezat PV PMID: 31199198 [PubMed - as supplied by publisher]
Abstract Ascending aortic aneurysm is usually associated with aortic valve diseases, especially aortic stenosis. The standard technique involves the substitution of the dilated aortic segment with a Dacron tube and replacement of the aortic valve with a regular prosthesis. The correction of ascending aortic aneurysm with aortic valve replacement using the new sutureless and rapid deployment prosthesis was performed by a minimally invasive approach and for the first time in a Brazilian Center.
Transcatheter aortic valve replacement (TAVR) has become a commonplace procedure for high-risk patient with aortic stenosis. A meta-analysis of 10,822 patients showed the rate of major vascular complications with second-generation closure devices to be 4.5%. Percutaneous approaches to arterial repairs demonstrate shorter length of stay and higher rate of direct to home discharge than with open approaches and equivalent outcomes at long-term follow-up. Our goal was to show that our vascular access strategy can decrease open repairs and improve patient outcomes.
This study examined gated cardiac CT scans to make observations regarding the size and proportions of the valve leaflets, sinuses of Valsalva, and sinotubular junction. One hundred and fifty gated cardiac CT scans were performed for a variety of clinical indications. Area of each cusp (short axis plane) was measured along with sinus height (from leaflet base to sinotubular junction), sinus width (from central coaptation point to outer sinus edge), annular perimeter, perimeter at mid-sinus level, and perimeter at the sinotubular junction. The right coronary cusp was largest, the left cusp smallest, and the non-coronary cusp...
AbstractPurpose of ReviewMultimodality imaging is integral for diagnosis, procedural guidance, and follow-up of patients undergoing transcatheter aortic valve replacement (TAVR). In this review, we provide an overview of the role of each imaging modality and highlight technical considerations and pitfalls. We also address current controversies and new developments in the field.Recent FindingsEchocardiography remains the primary imaging modality for diagnosis of aortic stenosis and intraprocedural guidance for TAVR, but computed tomography (CT) imaging has supplanted echocardiography for annular sizing and access site evalu...
This study sought to assess the baseline etiology and degree of MR in TAVI population, identify the predictors of MR changes and investigate the clinical and prognostic impact of baseline MR at mid and long-term follow-up.
Conditions: Heart Valve Diseases; Aortic Valve Disease; Heart Murmurs Intervention: Device: Vivio System Sponsor: Avicena LLC Not yet recruiting
Conclusion: Our center successfully implanted the self-expandable aortic valve Evolut™ via direct aortic for presenting a dissection in transverse aorta with possibilities of embolization. PMID: 31314003 [PubMed - in process]
Going beyond prior observational studies, a Mendelian randomization analysis provides strong evidence that raised systolic blood pressure leads to aortic stenosis and other valve disorders.Medscape Medical News
López-Andrés N Abstract Aortic stenosis is one of the most common heart valve diseases, as well as one of the most common causes of heart failure in the elderly. Currently, there are no medical therapies to prevent or slow the progression of the disease. When symptoms develop alongside severe aortic stenosis, there is a poor prognosis unless aortic valve replacement is performed. Aortic stenosis is a heterogeneous disease with a complex pathophysiology involving structural and biological changes of the valve, as well as adaptive and maladaptive compensatory changes in the myocardium and vasculature ...
We describe 2 cases of patients with stroke after TAVI who received tPA therapy and mechanical thrombectomy.