Gray matter volume changes following antipsychotic therapy in first-episode schizophrenia patients: A longitudinal voxel-based morphometric study

Publication date: Available online 15 June 2019Source: Journal of Psychiatric ResearchAuthor(s): Fan Guo, Yuan-Qiang Zhu, Chen Li, Xing-Rui Wang, Hua-Ning Wang, Wen-Ming Liu, Liu-Xian Wang, Ping Tian, Xiao-Wei Kang, Long-Biao Cui, Yi-Bin Xi, Hong YinAbstractDespite evidence of structural brain abnormalities in schizophrenia, the current study aimed to explore the effects of antipsychotic treatment on gray matter (GM) volume using structural magnetic resonance imaging (MRI) and investigate the relationship between brain structure and treatment response. The GM volumes of 33 patients with first-episode schizophrenia were calculated with voxel-based morphometry (VBM), with 33 matched healthy controls. Longitudinal volume changes within subjects after 4-month antipsychotic treatment were also evaluated. Correlation between volumetric changes and clinical symptoms derived from the Positive and Negative Syndrome Scale (PANSS) were further investigated. Compared with healthy controls, decreased GM volumes in the frontal gyrus were observed in schizophrenia patients. After 4-month treatment, patients showed significantly decreased GM volume primarily in the bilateral frontal, temporal and left parietal brain regions. In addition, the GM volume changes of the left postcentral gyrus was positively correlated with negative symptoms improvement, and the correlation analysis revealed the total PANSS scores changes were associated with GM volume changes in the right inferior frontal gyrus ...
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research