O-GlcNAcylation of Histone Deacetylase 4 Protects the Diabetic Heart from Failure.

CONCLUSIONS: In this study, we found that O-GlcNAcylation of HDAC4 at Ser-642 is cardio-protective in diabetes and counteracts pathological CaMKII signaling. We introduce a molecular model explaining how diabetic metabolism possesses important cardio-protective features besides its known detrimental effects. A deeper understanding of the here-described PTM crosstalk may lay the ground for the development of specific therapeutic concepts to treat heart failure in the context of diabetes.
PMID: 31195810 [PubMed - as supplied by publisher]

Source: Circulation - June 13, 2019 Category: Cardiology Authors: Kronlage M, Dewenter M, Grosso J, Fleming T, Oehl UY, Lehmann LH, Falcão-Pires I, Leite-Moreira AF, Volk N, Gröne HJ, Müller OJ, Sickmann A, Katus HA, Backs J Tags: Circulation Source Type: research