The Phosphatase PRL-3 Is Involved in Key Steps of Cancer Metastasis

Publication date: Available online 14 June 2019Source: Journal of Molecular BiologyAuthor(s): Laura Duciel, Luis Cristobal Monraz Gomez, Maria Kondratova, Inna Kuperstein, Simon SauleAbstractPRL-3 belongs to the PRL phosphatase family. Its physiological role remains unclear, but many studies have identified PRL-3 is a marker of cancer progression and shown it to be associated with metastasis. Evidence implicating PRL-3 in various elements of the metastatic process, such as the cell cycle, survival, angiogenesis, adhesion, cytoskeleton remodelling, EMT, motility and invasion has been reported. Furthermore, several molecules acting as direct or indirect substrates have been identified. However, this information was obtained in many different studies and it remains difficult to see the larger picture. We therefore systematically collected the published information together and used it to develop a comprehensive signalling network map. By analysing this network map, we were able to retrieve the signalling pathways via which PRL-3 governs the key steps of the metastatic process in cancer. In this review, we summarise current knowledge of the role of PRL-3 in cancer and the molecular mechanisms involved. We also provide the web-based open-source PRL-3 signalling network map, for use in further studies.Graphical abstract
Source: Journal of Molecular Biology - Category: Molecular Biology Source Type: research