Immune Exclusion Is Frequent in Small-Cell Carcinoma of the Bladder.

In conclusion, these data demonstrate that small-cell bladder cancer commonly exhibits an immune-excluded phenotype. PMID: 31191745 [PubMed - in process]
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research

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Publication date: Available online 11 July 2019Source: European UrologyAuthor(s): Filippo Pederzoli, Marco Bandini, Alberto Briganti, Elizabeth R. Plimack, Günter Niegisch, Evan Y. Yu, Aristotelis Bamias, Neeraj Agarwal, Srikala S. Sridhar, Cora N. Sternberg, Ulka N. Vaishampayan, Christine Théodore, Jonathan E. Rosenberg, Lauren C. Harshman, Joaquim Bellmunt, Matthew D. Galsky, Andrea Gallina, Andrea Salonia, Francesco Montorsi, Andrea NecchiAbstractThe availability of new potent systemic therapies for urothelial carcinoma may change the way we use standard chemotherapy perioperatively. In particular, identify...
Source: European Urology - Category: Urology & Nephrology Source Type: research
Conditions:   Bladder Cancer;   Urothelial Carcinoma Interventions:   Drug: 18F-fluciclovine;   Device: PET/CT Sponsors:   Dana-Farber Cancer Institute;   Blue Earth Diagnostics Not yet recruiting
Source: - Category: Research Source Type: clinical trials
AbstractThe Cancer Genome Atlas project introduced genomic taxonomy of basal and luminal molecular subtypes in muscle invasive bladder cancer. Fewer studies have addressed the molecular classification in non-muscle invasive bladder cancer (NMIBC). Our aim is to assess the applicability of the proposed phenotypic classification for NMIBC. Three TMAs were constructed from 193 TURBT specimens of 60 bladder cancer patients treated at one of the authors ’ institutions (1998–2008). Follow-up data on recurrence, grade, or stage progression was obtained. Immunohistochemistry was performed using an automated Ventana Sys...
Source: Virchows Archiv - Category: Pathology Source Type: research
Lynch Syndrome (LS) entails a defective DNA mismatch repair system, which is the post-replicative proofreading and editing system, ensuring our genome's integrity. LS predisposes to several cancers, most commonly colorectal and endometrial cancers. LS occurs in approximately 1 in 250 –1,000 people.LS is associated with urological malignancies with upper tract urothelial carcinoma the most common, although still clinically underestimated. Other urologic malignancies possibly associated with LS include bladder, prostate, testis, and renal cell carcinoma.
Source: Urology - Category: Urology & Nephrology Authors: Source Type: research
To report long-term outcomes with dose-escalated, image-guided adaptive radiotherapy (ART) for bladder preservation in muscle-invasive bladder cancer (MIBC).
Source: Clinical Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research
CONCLUSION: The multimodal treatment consisted of a maximal TUR-BT followed by RT; concomitant platinum-based chemotherapy combined with RHT in patients with high-grade bladder cancer improves local control, bladder-preservation rate, and OS. It offers a promising alternative to surgical therapies like radical cystectomy. IMPLICATIONS FOR PRACTICE: Radical cystectomy with appropriate lymph node dissection has long represented the standard of care for muscle-invasive bladder cancer in medically fit patients, despite many centers reporting excellent long-term results for bladder preserving strategies. This retrospective...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Oncologist Source Type: research
Nature Reviews Urology, Published online: 09 July 2019; doi:10.1038/s41585-019-0208-0In this Review, the authors discuss the molecular and histopathological evidence supporting pathology-driven therapy for advanced bladder cancer, including rare histological subtypes of urothelial carcinoma and non-urothelial carcinomas, and highlight novel molecular taxonomies, relevant biomarkers and promising future therapies.
Source: Nature Reviews Urology - Category: Urology & Nephrology Authors: Source Type: research
Abstract OBJECTIVES: We studied the effect of conditional survival on 5-year cancer-specific mortality (CSM) probability in a contemporary North-American population-based nonmetastatic urothelial carcinoma of urinary bladder cohort treated with radical cystectomy. METHODS AND MATERIALS: Within the SEER database (2004-2015), we identified pTa/pTis/pT1N0 high grade, pT2 to pT4N0 and pTanyN1-3 patients treated with radical cystectomy for nonmetastatic urothelial carcinoma of urinary bladder. Conditional 5-year CSM-free estimates were assessed after event-free follow-up duration. Multivariable Cox regression mode...
Source: Urologic Oncology - Category: Urology & Nephrology Authors: Tags: Urol Oncol Source Type: research
Publication date: Available online 5 July 2019Source: Pharmacological ResearchAuthor(s): Clarissa Esmeralda Halim, Shannon Lee Xinjing, Lu Fan, Jacqueline Bailey Vitarbo, Frank Arfuso, Chay Hoon Tan, Acharan S. Narula, Alan Prem Kumar, Gautam Sethi, Kwang Seok AhnAbstractOxymatrine (OMT) is a quinolizidine alkaloid derived from the roots of the Sophora genus plants. It has been widely used as a treatment for chronic hepatitis infections and inflammatory diseases due to its effective immunomodulatory and anti-inflammatory properties. Recently, the potential anti-cancer effects of OMT have been actively studied in various ca...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
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