Irpexlacte A-D, four new bioactive metabolites of endophytic fungus Irpex lacteus DR10-1 from the waterlogging tolerant plant Distylium chinense

Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Xiao-Xiang Duan, Dan Qin, Hong-Chuan Song, Tian-Cong Gao, Shi-Hao Zuo, Xiao Yan, Jun-Qi Wang, Xiao Ding, Ying-Tong Di, Jin-Yan DongAbstractOne new tremulane sesquiterpene, irpexlacte A (1), and three new furan derivatives, irpexlacte B–D (2-4), were isolated from the endophytic fungus Irpex lacteus DR10-1 waterlogging tolerant plant Distylium chinense, together with two known ones, irlactin E (5) and 3β-hydroxycinnamolide (6). Structures of these metabolites were characterized by HRESIMS and NMR spectroscopic methods. The antibacterial, anticancer and antioxidant activities of new compounds (1-4) were evaluated. 1-4 showed moderate antibacterial activity against Pseudomonas aeruginosa with MIC values ranging from 23.8 to 35.4 μM. 1 and 4 showed remarkable antioxidant activity with IC50 values of 2.50 and 5.75 μM respectively, which may contribute to the survival of D. chinense under waterlogging stress by eliminating the reactive oxygen species (ROS). Additionally, 1-5 may play important role on the sexual/asexual state of I. lacteus.Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research