Why a possible Alzheimer's drug may never be trialled

Publication date: 15 June 2019Source: New Scientist, Volume 242, Issue 3234Author(s): Debora MacKenzieAn arthritis drug might prevent Alzheimer's, but the firm that owns it isn't keen to develop it. Debora MacKenzie reports
Source: New Scientist - Category: Science Source Type: research

Related Links:

In this study, we identify a link between members of the genus Veillonella and exercise performance. We observed an increase in Veillonella relative abundance in marathon runners postmarathon and isolated a strain of Veillonella atypica from stool samples. Inoculation of this strain into mice significantly increased exhaustive treadmill run time. Veillonella utilize lactate as their sole carbon source, which prompted us to perform a shotgun metagenomic analysis in a cohort of elite athletes, finding that every gene in a major pathway metabolizing lactate to propionate is at higher relative abundance postexercise. Us...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
FDG-PET can help boost the detection of abnormalities associated with complex...Read more on AuntMinnie.comRelated Reading: SNMMI: Whole-body dynamic PET matches standard images SNMMI: PET spotlights link between Down syndrome, Alzheimer's SNMMI: PET ligand can diagnose brain disorder before autopsy SNMMI: Technetium radiotracer tracks rheumatoid arthritis SNMMI: FDG-PET/MRI improves pain diagnosis, management
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Abstract The glycation of proteins is a non-physiological post-translational incorporation of carbohydrates onto the free amines or guanidines of proteins and some lipids. Although the existence of glycated proteins has been known for forty years, a full understanding of their pathogenic nature has been slow in accruing. In recent years, however, glycation has gained wide-spread acceptance as a contributing factor in numerous metabolic, autoimmune and neurological disorders, tying together several confounding aspects of disease etiology. From diabetes, arthritis and lupus, to multiple sclerosis, amyotrophic latera...
Source: Combinatorial Chemistry and High Throughput Screening - Category: Chemistry Authors: Tags: Comb Chem High Throughput Screen Source Type: research
In this study, we determine whether transient reintroduction of embryonic stem cell cycle miR-294 promotes cardiomyocyte cell cycle reentry enhancing cardiac repair after myocardial injury. A doxycycline-inducible AAV9-miR-294 vector was delivered to mice for activating miR-294 in myocytes for 14 days continuously after myocardial infarction. miR-294-treated mice significantly improved left ventricular functions together with decreased infarct size and apoptosis 8 weeks after MI. Myocyte cell cycle reentry increased in miR-294 hearts parallel to increased small myocyte number in the heart. Isolated adult myocytes from miR-...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
ANAHEIM, CA - Researchers from the University of Wisconsin-Madison developed...Read more on AuntMinnie.comRelated Reading: Video from SNMMI 2019: Dr. Barry Siegel on PET reimbursement SNMMI: PET spotlights link between Down syndrome, Alzheimer's SNMMI: PET ligand can diagnose brain disorder before autopsy SNMMI: Technetium radiotracer tracks rheumatoid arthritis SNMMI: FDG-PET/MRI improves pain diagnosis, management
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Smoking tobacco takes a heavy toll on the immune system --a toll that can be...Read more on AuntMinnie.comRelated Reading: SNMMI: PET spotlights link between Down syndrome, Alzheimer's SNMMI: PET ligand can diagnose brain disorder before autopsy SNMMI: Technetium radiotracer tracks rheumatoid arthritis SNMMI: FDG-PET/MRI improves pain diagnosis, management SNMMI: PSMA-PET helps guide prostate cancer therapy
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
AbstractCurcumin is widely consumed in Asia either as turmeric directly or as one of the culinary ingredients in food recipes. The benefits of curcumin in different organ systems have been reported extensively in several neurological diseases and cancer. Curcumin has got its global recognition because of its strong antioxidant, anti ‐inflammatory, anti‐cancer, and antimicrobial activities. Additionally, it is used in diabetes and arthritis as well as in hepatic, renal, and cardiovascular diseases. Recently, there is growing attention on usage of curcumin to prevent or delay the onset of neurodegenerative diseases. This...
Source: BioFactors - Category: Biochemistry Authors: Tags: REVIEW ARTICLE Source Type: research
A rheumatoid arthritis drug may also cut the risk of developing Alzheimer ’s, but there are no plans to conduct the trials needed to find out if it really works
Source: New Scientist - Health - Category: Consumer Health News Source Type: research
Abstract Andrographolide is compound extracted from Andrographis paniculata (A. paniculata), a traditional herb that has been used in ancient China and other parts of eastern Asia to treat an array of disorders, such as cancer, rheumatoid arthritis, diarrhea, upper respiratory tract infection, and laryngitis, for a very long history. The mechanisms of action of andrographolide in disease prevention and/or therapy include anti-inflammation, anti-oxidative stress, anti-apoptosis, and/or pro-apoptosis. Pharmacodynamic studies have shown that andrographolide can cross the blood brain barrier and distribute into differ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
Pharmaceutical company Pfizer, based in New York, made a surprising finding about its arthritis drug in 2015 but didn't tell anyone because it 'thought the science wasn't strong enough'.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
More News: Alzheimer's | Arthritis | Rheumatology | Science