Efficacy of fluoxetine for anorexia nervosa caused by chemotherapy in patients with cholangiocarcinoma
Conclusion: The findings of this study will provide most recent evidence of fluoxetine for AN caused by chemotherapy in patients with cholangiocarcinoma. Systematic review registration: PROSPERO CRD42019131583.
ConclusionAblative therapies display promising potential as treatment modalities for iCCA. However, further research is necessary to validate these findings.
Publication date: Available online 19 August 2019Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Alexandra Simon, András Darcsi, Ágnes Kéry, Eszter RiethmüllerABSTRACTGinger, the rhizome of Zingiber officinale Roscoe is of great importance in the traditional medicine for the treatment of various diseases. More than 400 constituents have been reported in the plant, the most important ones being the gingerol and shogaol derivatives. Positive effects of ginger extracts and isolated -gingerol have been proved in animal models of anxiety, Alzheimer’s disease, Parkinson&rsqu...
In this study, the components of FP were profiled and characterized using HPLC-ESI-MS2. A total of 58 compounds were identified according to their fragmentation features in IT-TOF-MS and IT-MS2, including 13 phenolic acids, 17 flavonoids, 21 lignans, 2 alkaloids, and 5 other compounds. Among them, the identities of 8 compounds were explicitly confirmed by comparing them with standard compounds, and their contents were determined. Our study provided a comprehensive understanding of the diverse chemical profile in FP, and the approach we developed is useful for the analysis of other TCM formulas.
ConclusionsThe present study accurately and effectively identified QMs of J. amplexicaule that act as indicators of efficacy and quality.
ConclusionThese findings suggested that C. inerme leaves have potent antidiabetic and anti-oxidant activities. The results provide reliable scientific base, which is the premise for further research and development of CILE as supplements.
ConclusionHM might have some beneficial effects including improving insomnia, blood pressure, and mental health, for hypertensive elderly with insomnia. Since the methodological quality of the included studies and QoE were not high, well-designed RCTs are urgent to confirm these results.
AbstractPurposeTo report outcomes of salvage re-irradiation (re-RT) in recurrent/progressive medulloblastoma (MB).MethodsMedical records of patients treated with curative-intent re-RT as multi-modality management for recurrent/progressive MB between 2008 and 2018 were analyzed retrospectively.ResultsA total of 28 patients (median age 18 years at index diagnosis) were included. Molecular subgrouping was done using real-time reverse transcriptase polymerase chain reaction (RT-PCR) based on the differential expression of select set of 12 protein coding genes and 9 microRNAs. Fifteen of 17 (88%) patients with sonic hedge...
ConclusionsOur results suggest a role of decreased MPC1 copy number segments in reducing overall survival in glioblastoma. MPC1 deletion is associated with poor response to TMZ chemotherapy in GBM.
Publication date: Available online 18 August 2019Source: Journal of Anxiety DisordersAuthor(s): Casey L. Straud, Jedidiah Siev, Stephen Messer, Alyson K. ZaltaAbstractThere is conflicting evidence as to whether military populations (i.e., veteran and active-duty military service members) demonstrate a poorer response to psychotherapy for posttraumatic stress disorder (PTSD) compared to civilians. Existing research may be complicated by the fact that treatment outcomes differences could be due to the type of trauma exposure (e.g., combat) or population differences (e.g., military culture). This meta-analysis evaluated PTSD ...
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