Inhibitory Activities of Essential Oil Obtained from Turmeric and Its Constituents against β-Secretase.

In this study, the efficiency of collecting the essential oil using steam distillation of the volatile substance was disclosed The active principles were explored, and four sesquiterpenoids and five monoterpenoids were revealed as active principles against β-secretase; On the other hand, α-turmerone, β-turmerone and ar-turmerone were also investigated in a pharmacokinetic absorption experiment. After oral administration, these compounds were detected in an intact form in the brain and serum. These results suggest that consumption of-turieric constituents may prevent dementia. PMID: 30508333 [PubMed - indexed for MEDLINE]
Source: Natural Product Communications - Category: Biochemistry Tags: Nat Prod Commun Source Type: research