Downregulation of R-Spondin1 Contributes to Mechanical Stretch-Induced Lung Injury

Conclusions: Mechanical ventilation leads to down-regulation of R-spondin1. R-spondin1 may enhance the interaction of leucine-rich repeat containing G-protein coupled receptor 5 and apoptosis-stimulating protein of p53 2, thus inactivating p53-mediated proapoptotic pathway in cyclic stretched mouse lung vascular endothelial cells. R-spondin1 may have clinical benefit in alleviating mechanical ventilator-induced lung injury.
Source: Critical Care Medicine - Category: Emergency Medicine Tags: Online Laboratory Investigation Source Type: research