Multiplex quantitative analysis of stroma-mediated cancer cell invasion, matrix remodeling, and drug response in a 3D co-culture model of pancreatic tumor spheroids and stellate cells

Pancreatic ductal adenocarcinoma (PDAC) is a stroma-rich carcinoma, and pancreatic stellate cells (PSCs) are a major component of this dense stroma. PSCs play significant roles in metastatic progression and ch...

Source: Journal of Experimental and Clinical Cancer Research - June 14, 2019 Category: Cancer & Oncology Authors: Hyun Ju Hwang, Min-Suk Oh, Dong Woo Lee and Hyo-Jeong Kuh Tags: Research Source Type: research