Fc Characteristics Mediate Selective Placental Transfer of IgG in HIV-Infected Women

We examined the role of maternal HIV disease progression, infant factors, placental Fc receptor expression, IgG subclass, and glycan signatures and their association with placental IgG transfer efficiency. Maternal IgG characteristics, such as binding to placentally expressed Fc receptors FcγRIIa and FcγRIIIa, and Fc region glycan profiles were associated with placental IgG transfer efficiency. Our findings suggest that Fc region characteristics modulate the selective placental transfer of IgG, with implications for maternal vaccine design and infant health.Graphical Abstract
Source: Cell - Category: Cytology Source Type: research

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CONCLUSIONS: Lessons from the successful delivery of maternal tetanus immunization in Malawi may be informative for similar countries considering new vaccines for pregnant women or striving to optimize the delivery of those currently provided. PMID: 31319932 [PubMed - in process]
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
PMID: 31319931 [PubMed - in process]
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
PMID: 31319930 [PubMed - in process]
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
[East African] Kenya this week kicked off a five-day national polio vaccination campaign in areas with greatest risk of transmission as the United Nations warned that outbreaks in some countries in the Horn of Africa threaten Africa's and global efforts to eradicate the disease.
Source: AllAfrica News: Polio - Category: Infectious Diseases Source Type: news
Publication date: Available online 19 July 2019Source: Journal of Theoretical BiologyAuthor(s): Soyoung Kim, Eunok JungAbstractWe developed a mathematical model of the 2009 A/H1N1 influenza epidemic in the Republic of Korea by considering five age groups and suggested the best way to prioritize an age-dependent vaccination strategy for mitigating the epidemic. An age-structured SEIAR influenza model was constructed based on the laboratory confirmed data obtained from the Korea Centers for Disease Control and Prevention (KCDC). The estimated transmission matrix captured one of the main characteristics of the 2009 A/H1N1 inf...
Source: Journal of Theoretical Biology - Category: Biology Source Type: research
Authors: Ring N, Abrahams JS, Bagby S, Preston A, MacArthur I Abstract The evolution of Bordetella pertussis from a common ancestor similar to Bordetella bronchiseptica has occurred through large-scale gene loss, inactivation and rearrangements, largely driven by the spread of insertion sequence element repeats throughout the genome. B. pertussis is widely considered to be monomorphic, and recent evolution of the B. pertussis genome appears to, at least in part, be driven by vaccine-based selection. Given the recent global resurgence of whooping cough despite the wide-spread use of vaccination, a more thorough unde...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Authors: Stefanelli P Abstract Pertussis is a vaccine-preventable disease. Despite the high vaccination coverage among children, pertussis is considered a re-emerging disease for which identification, prevention and control strategies need to be improved. To control pertussis it is important to maintain a high vaccination coverage to protect the age groups considered at high risk for the disease. Laboratory confirmation of Bordetella pertussis infection together with a differential diagnostic test for other Bordetellae are prerequisite for a correct and timely diagnosis of pertussis. Moreover, investigations of ant...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Authors: Lambert EE, Buisman AM, van Els CACM Abstract Pertussis remains endemic in vaccinated populations due to waning of vaccine-induced immunity and insufficient interruption of transmission. Correlates of long-term protection against whooping cough remain elusive but increasing evidence from experimental models indicates that the priming of particular lineages of B. pertussis (Bp) specific CD4+ T cells is essential to control bacterial load. Critical hallmarks of these protective CD4+ T cell lineages in animals are suggested to be their differentiation profile as Th1 and Th17 cells and their tissue residency. ...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Publication date: July–August 2019Source: Biometric Technology Today, Volume 2019, Issue 7Author(s): Biometric tech specialists NEC and Simprints are jointly developing the world's first scalable child fingerprint ID system which they hope will boost immunisation levels among the 20 million children globally who still do not receive basic vaccines – leaving them exposed to some of the world's deadliest diseases.
Source: Biometric Technology Today - Category: Information Technology Source Type: research
Conclusion: A significant proportion of pregnant women have anti-HBs while the seroprevalence of HCV is low among pregnant women in the city of Mwanza. Routine screening of HBV among pregnant women coupled with appropriate management should be emphasized in developing countries. Further studies to determine seroprevalence of HCV are recommended across the country. PMID: 31316835 [PubMed - in process]
Source: Journal of Pregnancy - Category: OBGYN Tags: J Pregnancy Source Type: research
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