Could iPSCs Enable “Off-the-Shelf” Cell Therapy?

Publication date: 13 June 2019Source: Cell, Volume 177, Issue 7Author(s): Diana CrowAn “off-the-shelf” cell therapy derived from induced pluripotent stem cells (iPSCs) has entered clinical trials in the United States. Other companies are following suit, harnessing iPSCs’ self-renewal ability to manufacture cell therapies that don’t require customization for each patient. But some experts aren’t sure such therapies are a good idea.
Source: Cell - Category: Cytology Source Type: research

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Resumo O transplante de c élulas-tronco hematopoiéticas é um procedimento de alta complexidade que vem se constituindo como uma alternativa para algumas doenças potencialmente graves e desencadeadoras de uma série de afecções. A proposta deste estudo é examinar aquilo que o paciente experimenta durante o processo do transplante, especificamente, enquanto aguarda atendimento na sala de espera. Utilizando a narrativa como método de pesquisa, trabalha com o conceito de inconsciente, cuja referência é a teoria psicanalítica. Os resultados encont...
Source: Psicologia USP - Category: Psychiatry & Psychology Source Type: research
Hematopoietic stem cells (HSCs) resident in bone marrow generate immune cells, and their activity is thus vital to the correct function of the immune system. Like all stem cell populations, HSCs are sustained by a niche of supporting cells. One of the interesting questions relating to the aging of stem cells and the decline of stem cell activity in later life is whether this is a problem inherent to the stem cells themselves, or it arises from change and damage in the niche. There is evidence for both to be the case, but it is possible to argue that, until extreme old age, the loss of activity is more a matter of the niche...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Personalized Stem Cells, Inc. Announces FDA Approval of IND Application for Treatment of Osteoarthritis with Stem Cells(PRWeb July 22, 2019)Read the full story at
Source: PRWeb: Medical Pharmaceuticals - Category: Pharmaceuticals Source Type: news
ConclusionsFrom our data we conclude that hBMSC-derived exosomes overexpressing miR-34a may be instrumental for the therapeutic targeting and clinical management of GBM.
Source: Cellular Oncology - Category: Cancer & Oncology Source Type: research
Damu Tang Breast cancer stem cells (BCSC) play critical roles in the acquisition of resistance to endocrine therapy in estrogen receptor (ER)-positive (ER + ve) breast cancer (BC). The resistance results from complex alterations involving ER, growth factor receptors, NOTCH, Wnt/β-catenin, hedgehog, YAP/TAZ, and the tumor microenvironment. These mechanisms are likely converged on regulating BCSCs, which then drive the development of endocrine therapy resistance. In this regard, hormone therapies enrich BCSCs in ER + ve BCs under both pre-clinical and clinical settings along with upregulation of the core compo...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
ConclusionThe place of immunophenotyping in the diagnosis and treatment of this disorder is of significant importance. More research needs to be carried out to further comprehend the pathophysiology and treatment modalities for this disorder.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Swapna S Shanbhag, Chaitali N Patel, Ritin Goyal, Pragnya R Donthineni, Vivek Singh, Sayan BasuIndian Journal of Ophthalmology 2019 67(8):1265-1277 Simple limbal epithelial transplantation (SLET) is an innovative limbal stem cell transplantation technique that has gained increasing popularity over the last few years. Different groups from across the world have published the clinical results of SLET in large case series with varying types and severities of limbal stem cell deficiency (LSCD). This review attempts to place all the available knowledge on SLET together in one place for the benefit of not only cornea specialist...
Source: Indian Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research
Cell Death &Disease, Published online: 22 July 2019; doi:10.1038/s41419-019-1798-4Homocysteine enhances neural stem cell autophagy in in vivo and in vitro model of ischemic stroke
Source: Cell death and disease - Category: Internal Medicine Authors: Source Type: research
We report the high-resolution, anterior segment optical coherence tomography (OCT) features of the first 2 weeks of a patient undergoing SLET for an old acid injury of the right eye, repeatedly from postoperative day 1 through day 14. Three out of 11 explants with the subjacent human amniotic membrane (hAM) and the overlaid bandage contact lens were imaged. The hAM was intact and of the same thickness throughout the study period; the sub-hAM space increased from day 3 to 9 and disappeared by day 10; the explants started thinning from day 3 with the fibrin around them starting to decrease from day 2 and completely disappear...
Source: Indian Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research
Sushmita G Shah, Shreya M Shah, Juhee Agarwal, Ankita MulchandaniIndian Journal of Ophthalmology 2019 67(8):1382-1383
Source: Indian Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research
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