Does Regression Exist? Employing Biological Markers to Stratify Autism Spectrum Disorder (ASD)

Publication date: Available online 13 June 2019Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Atiqah Azhari, Farouq Azizan, Gianluca Esposito
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research

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The precise regulation of synaptic dopamine (DA) content by the DA transporter (DAT) ensures the phasic nature of the DA signal, which underlies the ability of DA to encode reward prediction error, thereby driving motivation, attention, and behavioral learning. Disruptions to the DA system are implicated in a number of neuropsychiatric disorders, including attention deficit hyperactivity disorder (ADHD) and, more recently, autism spectrum disorder (ASD). An ASD-associated de novo mutation in the SLC6A3 gene resulting in a threonine-to-methionine substitution at site 356 (DAT T356M) was recently identified and has been show...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Genetics in Medicine, Published online: 23 July 2019; doi:10.1038/s41436-019-0610-2Nonrandom occurrence of multiple de novo coding mutations in a proband indicates the existence of an oligogenic model in autism
Source: Genetics in Medicine - Category: Genetics & Stem Cells Authors: Source Type: research
(Natural News) Researchers from the Hong Kong Baptist University have found that scalp acupuncture can potentially be used to treat symptoms of autism spectrum disorder (ASD). In their paper, they reported that children stand to benefit the most from this procedure, based on the results of their trial. “We observed a better improvement in children...
Source: - Category: Consumer Health News Source Type: news
Scientists from University College London said the findings held up in neurotypical people and in those diagnosed with autism.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Research finds recording of spontaneous laughter is more effective than controlled oneIn research that will ensure the sitcoms of the future are as painful as those broadcast today, scientists have found that canned laughter makes bad jokes seem funnier.The impact ofoverlaid laughter emerged from a study with autistic and “neurotypical” people, all of whom agreed to endure 40 jokes that were read aloud with recorded laughter following the punchline.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Neuroscience World news TV comedy Television & radio Culture Source Type: news
For years scientists have said that there is no link between vaccines and autism. There are still many people who are reluctant to vaccinate. But, one woman has changed her mind about vaccines.
Source: NPR Health and Science - Category: Consumer Health News Authors: Source Type: news
ConclusionLicensed drivers with ASD were found to allocate visual attention differently compared to licensed drivers without ASD. Poor scanning patterns with an over-focus on the road ahead and less scanning of the road side and periphery may possibly result in unsafe driving. However, risk-taking behaviour was not prevalent in these drivers. Effective visual scanning strategies could be incorporated in the driver training of individuals with ASD.
Source: Journal of Transport and Health - Category: Occupational Health Source Type: research
AbstractBackgroundLower gestational age may increase autism spectrum disorder (ASD) vulnerability; however, the incidence of ASD diagnosis through a direct assessment on every very preterm birth child on the population base remains unclear. Moreover, the behavioral characteristics of preterm birth ASD are unknown.MethodsEvery very preterm birth child (gestational age
Source: Molecular Autism - Category: Molecular Biology Source Type: research
ConclusionsThis work could lead to the potential repurposing of nicardipine or other dihydropyridine calcium channel antagonists as potential treatments for PTHS acting via Nav1.8, as there are currently no approved treatments for this rare disorder.
Source: Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research
Behavioral comorbidity is the rule rather than the exception in autism spectrum disorder (ASD), and the co-occurrence of autistic traits with subclinical manifestations of other psychiatric syndromes (e.g. anxiety, developmental coordination disorder) extends to the general population, where there is strong evidence for overlap in the respective genetic causes. An ASD “comorbidity” can have several fundamentally-distinct causal origins: it can arise due to shared genetic risk between ASD and non-ASD phenotypes (e.g., ASD and microcephaly in the context of the MECP2 mutation), as a “secondary symptom&rdquo...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - Category: Psychiatry Authors: Tags: In Context Source Type: research
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