Light at night exacerbates metabolic dysfunction in a polygenic mouse model of type 2 diabetes mellitus

In conclusion, LAN exacerbated metabolic abnormalities in a polygenic mouse model of T2DM, and these effects were reversed upon return to dark nights. The applicability of these findings to humans with T2DM needs to be determined.
Source: Life Sciences - Category: Biology Source Type: research

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This study was conducted to find a correlation between thyroid profile and sepsis and associate it with the acute physiology and chronic health evaluation II (APACHE II) score. Background: :A cross-sectional study was conducted from January 2015 to December 2015 at the Department of Medicine, KLES Dr. Prabhakar Kore Hospital and Medical Research Center, Belagavi. A total of 100 patients aged 18 years or more fulfilling the sepsis criteria were included in the study. Patients were subjected to clinical examination followed by systemic examination. The clinical severity as well as the prediction of outcome was assessed b...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Authors: Agrawal P, Gautam A, Pursnani N, Maheshwari PK Abstract Context: Increasing diabetic burden worldwide is creating an alarming situation for the management and development of economic resources for it's treatment. Progressive nature of the disease requires allocation of a higher proportion of expenditure on health care initiative of any country. Aim: Present study is designed with an aim to determine the effectiveness of cost-effective DPP-4 inhibitor, Teneligliptin, over the other agent of the same class. Material and Method: The study was carried out in Postgraduate Department of Medicine, S.N. Me...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Conclusions: This study suggested that, KCNQ1 being an established type 2 diabetes gene, genetic variation in this gene may contribute to susceptibility to diabetic nephropathy and the C allele is the risk allele for diabetic nephropathy, which is different from Japanese population where the T allele was the risk allele. PMID: 31324086 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Authors: Patil P, Darshan A, Ao S, Kothiwale VA Abstract Objective: To study the association of MPV (mean platelet volume) and acute ischemic stroke in patients of type 2 diabetes mellitus (DM). Material: This was a 1-year cross-sectional hospital-based study involving 79 patients presented with acute ischemic stroke. Among them, 25 were diabetic and 54 were nondiabetic. Demographic data and history of the patients were recorded. Investigations such as haemoglobin estimation, platelet count, MPV, HbA1c, imaging studies were conducted and evaluated for acute ischemic brain stroke. All the patients underwent neur...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Authors: Mokta JK, Ramesh, Sahai AK, Kaundal PK, Mokta K Abstract Objectives: To compare the safety and efficacy of combination of Glimepiride - Metformin with Vildagliptin - Metformin in type 2 diabetic patients with HbA1c between 7.5to10. Methods: A randomized, prospective, comparative and interventional study was conducted at Indira Gandhi Medical College, Shimla. The level of hemoglobin A1c (HbA1c), fasting blood sugar (FBS) and postprandial blood sugar (PP) were the primary outcomes, whereas, the evidence of hypoglycemia, quality of life and weight gain were recorded as secondary outcomes. 215 patients new...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Conclusion: Type 2 diabetes mellitus can present with or without symptoms and with chronic vascular complications at the time of diagnosis, opportunistic screening for diabetes should be done in high risk patients along with screening for the vascular complications. PMID: 31324080 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Conclusion: Our study results suggest that abnormal pupil functions due to diabetic autonomic neuropathy may indicate the associated ED in patients with DM.
Source: Indian Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research
AbstractObjectiveTo evaluate the effect ofHelicobacter pylori (H. pylori) infection upon metabolic and inflammatory parameters in type 2 diabetes mellitus (T2DM).MethodsA total of 72 patients with T2DM were included in the study. These patients were divided into two groups asH. pylori infection positive or negative. For each patient, the following data were collected: age, gender, duration of diabetics, anti-diabetic treatment, the body mass index (BMI), and laboratory parameters (lipid profile, GLU, HbA1c, HCY, HsCRP, ghrelin, leptin, leukocyte, and platelet counts).ResultsTotally 47 patients (65.28%) wereH. pylori positi...
Source: International Journal of Diabetes in Developing Countries - Category: Endocrinology Source Type: research
Diabetes mellitus, especially type 2 diabetes mellitus (T2DM), has become a significant public health burden. Rhizoma coptidis (RC), known as huanglian, is widely used for treating diabetes in China. The bioactive compounds of RC, especially alkaloids have the potential to suppress T2DM-induced lesions, including diabetic vascular dysfunction, diabetic heart disease, diabetic hyperlipidemia, diabetic nephropathy, diabetic encephalopathy, diabetic osteopathy, diabetic enteropathy and diabetic retinopathy. This review summarizes the effects of RC and its bioactive compounds on T2DM and T2DM complications. Less research has b...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Authors: Gupta P, Gupta R, Gupta AK Abstract The chronic complications of Diabetes Mellitus (DM), which may be present in as many as 50% of the patients at the time of diagnosis, are a major burden for both individuals with the disease and health systems and it has been estimated that as much as 60-70% of healthcare expenditure related to diabetes (about 670 billion dollars a year) is currently attributable to chronic complications of the disease. These high prevalence rates are widely acknowledged to further rise as poor lifestyle choices and their consequences continue to rise. Adding to that is an aging populati...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
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