DEPDC1 promotes cell proliferation and suppresses sensitivity to chemotherapy in human hepatocellular carcinoma.

In this study, we aimed to characterize the biological role of DEPDC1 in HCC and illuminate the potential molecular mechanisms. Here we found that DEPDC1 was significantly up-regulated in HCC tissues compared with adjacent normal tissues. Besides, the log-rank test and Kaplan-Meier survival analysis demonstrated that patients with high DEPDC1 expression experienced a significantly shorter overall survival. Functional investigations showed that DEPDC1 over-expression facilitated HCC cell proliferation and suppressed cell apoptosis, whereas DEPDC1 depletion inhibited HCC cell proliferation and promoted cell apoptosis. In addition, DEPDC1 ablation repressed tumorigenecity of HCC cells in murine xenograft models. Mechanistic studies demonstrated that JNK signaling pathway mediated the promoting effects of DEPDC1 on HCC cell viability and chemotherapy resistance. Taken together, our data indicate that DEPDC1 promotes cell proliferation and inhibits sensitivity to chemotherapy in HCC through activation of JNK signaling pathway. Therefore, this study may provide some evidence for DEPDC1 as a candidate therapeutic target for HCC. PMID: 31189746 [PubMed - as supplied by publisher]
Source: Bioscience Reports - Category: Biomedical Science Authors: Tags: Biosci Rep Source Type: research